Solubility, metastable zone, and cooling crystallization process of dodecanedioic acid investigated by focused-beam reflectance measurement technology

IF 2.8 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of chemical technology and biotechnology Pub Date : 2025-04-25 DOI:10.1002/jctb.7881

Jiulong Duan, Miaomiao Zhu, Xingjie Ma, Lihong Liu, Jin Huang

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引用次数: 0

Abstract

BACKGROUND

Dodecanedioic acid (DC₁₂) is widely used as a chemical intermediate in nylon synthesis but its separation and purification are crucial for producing high-quality DC₁₂. Herein, the solubility characteristics of DC₁₂ in various solvents (ethanol, isopropanol, ethyl acetate, 1,4-dioxane, Dimethyl sulfoxide (DMSO), and N,N-dimethylformamide (DMF)) were investigated by focused-beam reflectance measurement technology.

RESULTS

Based on the results of solubility data simulation to the modified equations of Apelblat and λh, the former equation model of Apelblat yielded the best-fitting performance. Subsequently, thermodynamic properties of DC₁₂ in the six solvents were investigated and the results identified increasing endothermic and entropy as the dissolution processes of DC₁₂ in all solvents. The thermodynamic analyses also revealed 1,4-dioxane as the best solvent for the cooling crystallization of DC₁₂. The measured metastable zone width (MSZW) of DC₁₂ cooling crystallization in 1,4-dioxane displayed a decline as a function of the decrease in cooling rate and increase in stirring speed.

CONCLUSION

The optimal process parameters for the cooling crystallization of DC₁₂ in 1,4-dioxane were determined as solid–liquid ratio of 1:5 g mL⁻¹, stirring speed of 200 rpm, and solution preparation temperature of 70 °C. To the best of our knowledge, the proposed method for crystallization of DC₁₂ with 1,4-dioxane solvent is reported for the first time and has potential for future industrial application in DC₁₂ production. © 2025 Society of Chemical Industry (SCI).

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用聚焦光束反射测量技术研究了十二烷二酸的溶解度、亚稳区和冷却结晶过程

十二烷二酸（DC12）作为一种广泛应用于尼龙合成的化学中间体，其分离纯化对生产高质量的DC12至关重要。本文采用聚焦光束反射测量技术研究了DC12在不同溶剂（乙醇、异丙醇、乙酸乙酯、1,4-二氧六环、二甲亚砜（DMSO）和N，N-二甲基甲酰胺（DMF））中的溶解度特性。结果对修正后的Apelblat方程和λh方程进行溶解度数据模拟结果表明，修正后的Apelblat方程模型拟合效果最好。随后，研究了DC12在6种溶剂中的热力学性质，结果表明DC12在所有溶剂中的溶解过程都是吸热和熵的增加。热力学分析还表明，1,4-二恶烷是DC12冷却结晶的最佳溶剂。DC12在1,4-二恶烷中冷却结晶的亚稳区宽度（MSZW）随冷却速度的减小和搅拌速度的增加而减小。结论DC12在1,4-二氧六环中冷却结晶的最佳工艺参数为料液比1:5 g mL−1，搅拌速度200 rpm，溶液制备温度70℃。据我们所知，本文提出的用1,4-二氧六环溶剂结晶DC12的方法是首次报道，在DC12生产中具有未来工业应用的潜力。©2025化学工业学会（SCI）。

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来源期刊

Journal of chemical technology and biotechnology 工程技术-工程：化工

CiteScore

7.00

自引率

5.90%

发文量

268

审稿时长

1.7 months

期刊介绍： Journal of Chemical Technology and Biotechnology(JCTB) is an international, inter-disciplinary peer-reviewed journal concerned with the application of scientific discoveries and advancements in chemical and biological technology that aim towards economically and environmentally sustainable industrial processes.