MRI for assessing abdominal organs iron concentration: A comparative study between the relaxometry methods

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-06-06 DOI:10.1016/j.ejrad.2025.112226

Chaotian Luo , Fei Peng , Xiaojing Ning , Cheng Tang , Mingrui Yang , Linlin Liang , Fangyan Xiao , Yanyan Zhang , Fuling Huang , Peng Peng

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引用次数: 0

Abstract

Objective

To compare magnetic resonance imaging (MRI) commercial 3D quantitative Dixon sequence (qDixon) and 2D multi-gradient recalled echo sequence (GRE) for iron quantification in multiple abdominal organs.

Methods

1.5T MRI GRE and qDixon data were collected on patients with 211 MR exams from 171 patients (86 males, 85 females; median age: 21 years). Compare the R2* values of liver, pancreas, spleen, and kidneys using Bland-Altman, intraclass correlation coefficients (ICC), concordance correlation coefficients (CCC), and linear regression. Iron overload (IO) diagnostic concordance was assessed using overall agreement and the Kappa coefficient.

Results

Bland-Altman analysis of liver, pancreas, spleen, and kidney R2* values between GRE and qDixon, resulted in a bias (absolute mean difference) of −11.3 1/s (LoA: 77.7 and −100.3), −11.2 1/s (LoA: 123.9 and −146.3), 5.1 1/s (LoA: 117.3 and −107.1), and 1.9 1/s (LoA: 14.7 and −10.9). The CCCs between GRE and qDixon R2* values for liver, pancreas, spleen, and kidneys were 0.98, 0.94, 0.96, and 0.95, the ICCs were 0.99, 0.95, 0.96, and 0.97, respectively. Linear regression analysis correlating abdominal organs R2* values of GRE and qDixon resulted in a coefficient of determination of 0.96, 0.89, 0.93, and 0.92 (all P < 0.001). The overall agreement was 98.5 %, 94.8 %, 92.6 %, and 90.7 %; the Kappa value was 0.95, 0.89, 0.84, and 0.69 (all P < 0.001).

Conclusion

The qDixon and GRE showed good agreement and significant positive in measuring R2* values for IO assessment in abdominal organs, with qDixon being an excellent adjunctive diagnostic method.

Abstract Image

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磁共振成像评估腹部器官铁浓度：弛豫测量方法的比较研究

目的比较磁共振成像（MRI）商用三维定量Dixon序列（qDixon）和二维多梯度回忆回声序列（GRE）对腹部多脏器铁定量的影响。方法收集171例患者211例MR检查的1.5 t MRI GRE和qDixon数据(男86例，女85例；中位年龄：21岁)。采用Bland-Altman、类内相关系数（ICC）、一致性相关系数（CCC）和线性回归比较肝脏、胰腺、脾脏和肾脏的R2*值。铁超载（IO）诊断一致性评估使用总体协议和Kappa系数。结果bland - altman分析GRE和qDixon之间肝脏、胰腺、脾脏和肾脏的R2*值，偏差（绝对平均差）分别为- 11.3 1/s （LoA: 77.7和- 100.3）、- 11.2 1/s （LoA: 123.9和- 146.3）、5.1 1/s （LoA: 117.3和- 107.1）和1.9 1/s （LoA: 14.7和- 10.9）。肝脏、胰腺、脾脏和肾脏的GRE和qDixon R2*值CCCs分别为0.98、0.94、0.96和0.95，ICCs分别为0.99、0.95、0.96和0.97。对腹部脏器GRE和qDixon R2*值进行线性回归分析，其决定系数分别为0.96、0.89、0.93和0.92(均P <；0.001)。总体一致度分别为98.5%、94.8%、92.6%、90.7%；Kappa值分别为0.95、0.89、0.84和0.69 (P <；0.001)。结论qDixon与GRE在测量腹部脏器IO评估R2*值时一致性较好，呈显著阳性，qDixon是一种很好的辅助诊断方法。

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.