Statin use is associated with reduced risk of incident intracerebral hemorrhage: A prospective population-based cohort study.

IF 8.7 2区医学 Q1 CLINICAL NEUROLOGY

International Journal of Stroke Pub Date : 2025-06-10 DOI:10.1177/17474930251351103

Xiao Hu, Zijie Wang, Jincheng Liu, Xueyun Liu, Jiaxin Luo, Zizhen Meng, Tiannan Yang, Qi Li

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引用次数: 0

Abstract

Background: The association between statin use and the risk of incident intracerebral hemorrhage (ICH) remains controversial, with concerns about a potential increased risk of ICH among statin users.

Aims: This study aimed to investigate the association between statin use and incident ICH in the general population.

Methods: This prospective cohort study utilized data from UK Biobank. Cox proportional regression models were employed to estimate hazard ratios (HRs) for the association between statin use and incident ICH in both unmatched and propensity score-matched (PSM) cohorts, adjusting for sociodemographic characteristics, lifestyle factors, comorbidities, and concurrent medication use.

Results: A total of 421,444 participants were included in the final analysis, with a median age of 58.0 years (interquartile range [IQR]: 50.0-63.0), and 53.9% were female. At baseline, 69,272 individuals reported regular statin use. Over a median follow-up period of 12.75 years (IQR: 11.30-14.21), 1533 participants (0.4%) experienced incident ICH. Multivariate Cox regression analyses showed that statin use was significantly associated with a reduced risk of ICH in the fully adjusted model (aHR 0.77; 95% CI 0.66-0.90). This association was significant among individuals without a history of coronary artery disease, stroke or transient ischemic attack (aHR 0.75; 95% CI 0.63-0.89). Potential interaction effects were identified between statin use and age (p for interaction = 0.027 in the total cohort), waist-to-hip ratio, and low-density lipoprotein cholesterol levels (p for interaction = 0.025 and 0.062, respectively, in the PSM cohort) in relation to ICH risk.

Conclusion: In this large population-based study, statin use was associated with a reduced risk of incident ICH, providing further evidence for the long-term safety of statin therapy with respect to ICH risk in the general population and across diverse subgroups.Data access statement:UK Biobank database is available on application by approved researchers.

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他汀类药物的使用与脑出血发生率降低相关：一项前瞻性人群队列研究

背景：他汀类药物的使用与脑出血风险之间的关系仍然存在争议，人们担心他汀类药物使用者可能增加脑出血风险。目的：本研究旨在调查普通人群中他汀类药物使用与脑出血事件之间的关系。方法：这项前瞻性队列研究利用了英国生物银行的数据。采用Cox比例回归模型估计未匹配和倾向评分匹配（PSM）队列中他汀类药物使用与脑出血事件之间关联的风险比（hr），调整社会人口统计学特征、生活方式因素、合并症和并发用药。结果：最终分析共纳入421,444名参与者，中位年龄58.0岁（四分位数间距[IQR]: 50.0 ~ 63.0），女性占53.9%。在基线时，69,272人报告定期使用他汀类药物。中位随访期为12.75年（IQR: 11.30-14.21）， 1533名参与者（0.4%）发生脑出血事件。多因素Cox回归分析显示，在完全调整模型中，他汀类药物的使用与脑出血风险降低显著相关(aHR 0.77；95% ci 0.66-0.90)。这种关联在没有冠状动脉疾病、中风或短暂性脑缺血发作史的个体中是显著的(aHR 0.75；95% ci 0.63-0.89)。他汀类药物的使用与年龄（总队列中相互作用的P值= 0.027）、腰臀比和低密度脂蛋白胆固醇水平（PSM队列中相互作用的P值分别= 0.025和0.062）之间存在潜在的相互作用效应。结论：在这项以人群为基础的大型研究中，他汀类药物的使用与脑出血风险的降低有关，这进一步证明了他汀类药物治疗在普通人群和不同亚组脑出血风险方面的长期安全性。数据访问声明：UK Biobank数据库可通过批准的研究人员申请。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Stroke 医学-外周血管病

CiteScore

13.90

自引率

6.00%

发文量

132

审稿时长

6-12 weeks

期刊介绍： The International Journal of Stroke is a welcome addition to the international stroke journal landscape in that it concentrates on the clinical aspects of stroke with basic science contributions in areas of clinical interest. Reviews of current topics are broadly based to encompass not only recent advances of global interest but also those which may be more important in certain regions and the journal regularly features items of news interest from all parts of the world. To facilitate the international nature of the journal, our Associate Editors from Europe, Asia, North America and South America coordinate segments of the journal.