Trends and Predictors of Total Neoadjuvant Therapy in Rectal Cancer: A Bi-National Registry Study Across Australia and New Zealand.

IF 1.6 4区 医学 Q3 SURGERY
Ishraq Murshed, Sergei Bedrikovetski, Zachary Bunjo, Hidde M Kroon, Michelle Thomas, Tarik Sammour
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引用次数: 0

Abstract

Background: Total Neoadjuvant Therapy (TNT) has significantly improved outcomes in locally advanced rectal cancer. Despite rising use and inclusion in international guidelines, adoption patterns in Australia and New Zealand (ANZ) remain unclear. This study determines bi-national patterns and predictors of TNT utilisation over a 6-year period.

Methods: A retrospective population-based bi-national registry cohort study analysed data from the ANZ Bowel Cancer Outcome Registry from 2018 to 2024. Patients diagnosed with primary locally advanced rectal cancer (LARC) and treated with standard neoadjuvant therapy (SNT), consisting of long-course chemoradiotherapy or short-course radiotherapy, or TNT were included. The primary outcome was the incidence of TNT utilisation over time and determining pre-treatment predictive factors.

Results: Of 33 270 patient entries, 3234 eligible LARC patients were identified, with 706 (21.8%) receiving TNT and 2528 (78.2%) receiving SNT. TNT usage increased from 11% in 2018 to 41% in 2023. On multivariable logistic regression, independent factors associated with decreased TNT use were older age (OR: 0.978, 95% CI: 0.970-0.985, p < 0.001), absence of multidisciplinary team discussion (OR: 0.113, 95% CI: 0.027-0.472, p = 0.003) and private health insurance (OR: 0.619, 95% CI: 0.441-0.869, p = 0.006). Factors associated with increased TNT use were clinical T4 tumours (OR: 2.020, 95% CI: 1.245-3.280, p = 0.004), node-positive status (OR: 1.481, 95% CI: 1.118-1.964, p = 0.006) and diagnosis during the years 2019-2023 (p < 0.05 for all).

Conclusions: TNT is increasingly used in surgical rectal cancer patients captured in the BCOR in ANZ. This study provides a baseline for future benchmarking patterns of rectal cancer management.

直肠癌新辅助治疗的趋势和预测因素:澳大利亚和新西兰的两国注册研究。
背景:全面新辅助治疗(TNT)能显著改善局部晚期直肠癌的预后。尽管越来越多的使用和纳入国际指导方针,但澳大利亚和新西兰(ANZ)的采用模式仍不清楚。这项研究确定了两国在6年期间TNT利用的模式和预测因素。方法:一项基于人群的回顾性双国登记队列研究分析了澳新银行肠癌结局登记中心2018年至2024年的数据。诊断为原发性局部晚期直肠癌(LARC)并接受标准新辅助治疗(SNT)的患者,包括长疗程放化疗或短疗程放疗或TNT。主要结果是随时间推移TNT使用的发生率和确定治疗前的预测因素。结果:在33270例入组患者中,鉴定出3234例符合条件的LARC患者,其中706例(21.8%)接受TNT治疗,2528例(78.2%)接受SNT治疗。TNT的使用量从2018年的11%增加到2023年的41%。在多变量logistic回归中,与TNT使用减少相关的独立因素是年龄较大(OR: 0.978, 95% CI: 0.970-0.985, p)。结论:澳新地区BCOR中发现的外科直肠癌患者越来越多地使用TNT。本研究为未来直肠癌管理的基准模式提供了一个基线。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ANZ Journal of Surgery
ANZ Journal of Surgery 医学-外科
CiteScore
2.50
自引率
11.80%
发文量
720
审稿时长
2 months
期刊介绍: ANZ Journal of Surgery is published by Wiley on behalf of the Royal Australasian College of Surgeons to provide a medium for the publication of peer-reviewed original contributions related to clinical practice and/or research in all fields of surgery and related disciplines. It also provides a programme of continuing education for surgeons. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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