The role of Bifidobacterium animalis QC08 in antibiotic-associated diarrhea in mice.

IF 2.4 3区农林科学 Q3 FOOD SCIENCE & TECHNOLOGY

Food Science and Biotechnology Pub Date : 2025-05-15 eCollection Date: 2025-07-01 DOI:10.1007/s10068-025-01881-4

Lixuan Ren, Fang Tan, Hyo-Eun Kim, Xin Ma, Chang-Suk Kong

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Abstract

Excessive antibiotic use can lead to gut microbiota dysbiosis, resulting in diarrhea. This study aimed to investigate the effects of Bifidobacterium animalis QC08 (QC08) on the antibiotic-induced diarrhea mouse model using lincomycin hydrochloride. Mice were divided into five groups: normal, diarrhea, a drug group, high-dose QC08 (QC08-H), low-dose QC08 (QC08-L). Compared with the diarrhea group, the QC08-H and QC08-L groups showed a decrease in serum serotonin, interleukin (IL)-17A, IL-6, and malondialdehyde levels, whereas total antioxidant capacity levels increased. In the colon and small intestine tissues of QC08-H and QC08-L treated mice, mRNA expression of cystic fibrosis transmembrane conductance regulator (CFTR), epidermal growth factor receptor (EGFR), and transforming growth factor β1 (TGFβ1) was significantly downregulated, whereas expression of sodium-hydrogen exchanger 1 (NHE1) and NHE4 was upregulated compared to the AAD model group. Altogether, this in vivo study demonstrates the potential of QC08 in alleviating AAD in mice, providing valuable insights for understanding and potentially treating antibiotic-related gut issues.

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动物双歧杆菌QC08在小鼠抗生素相关性腹泻中的作用。

过量使用抗生素会导致肠道菌群失调，导致腹泻。本研究旨在探讨动物双歧杆菌QC08 （QC08）对盐酸林可霉素抗生素性腹泻小鼠模型的影响。将小鼠分为正常组、腹泻组、给药组、高剂量QC08 （QC08- h）、低剂量QC08 (QC08- l) 5组。与腹泻组相比，QC08-H和QC08-L组血清血清素、白细胞介素-17A、IL-6和丙二醛水平降低，总抗氧化能力水平升高。与AAD模型组相比，QC08-H和QC08-L处理小鼠结肠和小肠组织中囊性纤维化跨膜传导调节剂（CFTR）、表皮生长因子受体（EGFR）和转化生长因子β1 (tgf - β1) mRNA表达显著下调，而钠氢交换剂1 （NHE1）和NHE4表达上调。总之，这项体内研究证明了QC08在缓解小鼠AAD方面的潜力，为理解和潜在地治疗抗生素相关的肠道问题提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food Science and Biotechnology FOOD SCIENCE & TECHNOLOGY-

CiteScore

5.40

自引率

3.40%

发文量

174

审稿时长

2.3 months

期刊介绍： The FSB journal covers food chemistry and analysis for compositional and physiological activity changes, food hygiene and toxicology, food microbiology and biotechnology, and food engineering involved in during and after food processing through physical, chemical, and biological ways. Consumer perception and sensory evaluation on processed foods are accepted only when they are relevant to the laboratory research work. As a general rule, manuscripts dealing with analysis and efficacy of extracts from natural resources prior to the processing or without any related food processing may not be considered within the scope of the journal. The FSB journal does not deal with only local interest and a lack of significant scientific merit. The main scope of our journal is seeking for human health and wellness through constructive works and new findings in food science and biotechnology field.