Decoding extracellular matrix–lysosome cross-talk and its implications for neurodegenerative diseases

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Science Signaling Pub Date : 2025-06-10 DOI:10.1126/scisignal.adt1936

Qinghu Yang, Huan Ma, Liang Yang, Ming Jiang, Xia Liu, Zhantao Bai

引用次数: 0

Abstract

Lysosomes are versatile organelles that play pivotal roles in cellular recycling and signal transduction. They are crucial for the autophagic degradation and recycling of macromolecules, which facilitates the efficient turnover of cellular components. Beyond their intracellular roles, lysosomes also regulate the degradation and assembly of extracellular matrix (ECM) constituents, affecting ECM remodeling and the processing of signaling molecules essential for cellular communication and adaptation to the microenvironment. Conversely, the ECM regulates key lysosomal functions, including biogenesis, acidification, and subcellular positioning. In this Review, we discuss the bidirectional interaction between lysosomes and the ECM and explore its implications in the development and treatment of neurodegenerative disease.

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细胞外基质-溶酶体串扰的解码及其对神经退行性疾病的意义

溶酶体是多功能细胞器，在细胞循环和信号转导中起着关键作用。它们对于大分子的自噬降解和再循环至关重要，这有助于细胞成分的有效周转。除了细胞内的作用，溶酶体还调节细胞外基质（ECM）成分的降解和组装，影响细胞外基质的重塑和细胞通讯和适应微环境所必需的信号分子的加工。相反，ECM调节关键的溶酶体功能，包括生物发生、酸化和亚细胞定位。在这篇综述中，我们讨论了溶酶体和ECM之间的双向相互作用，并探讨其在神经退行性疾病的发展和治疗中的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Signaling BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY

CiteScore

9.50

自引率

0.00%

发文量

148

审稿时长

3-8 weeks

期刊介绍： "Science Signaling" is a reputable, peer-reviewed journal dedicated to the exploration of cell communication mechanisms, offering a comprehensive view of the intricate processes that govern cellular regulation. This journal, published weekly online by the American Association for the Advancement of Science (AAAS), is a go-to resource for the latest research in cell signaling and its various facets. The journal's scope encompasses a broad range of topics, including the study of signaling networks, synthetic biology, systems biology, and the application of these findings in drug discovery. It also delves into the computational and modeling aspects of regulatory pathways, providing insights into how cells communicate and respond to their environment. In addition to publishing full-length articles that report on groundbreaking research, "Science Signaling" also features reviews that synthesize current knowledge in the field, focus articles that highlight specific areas of interest, and editor-written highlights that draw attention to particularly significant studies. This mix of content ensures that the journal serves as a valuable resource for both researchers and professionals looking to stay abreast of the latest advancements in cell communication science.