Anion influence on the structure and cytotoxicity of Copper(II) complexes based on 2,2’-bipyridine/1,10-phenanthroline and benzimidazole derivative

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2025-06-05 DOI:10.1016/j.ica.2025.122803

Yu.A. Golubeva , E.A. Ermakova , K.S. Smirnova , L.S. Klyushova , N.P. Zaytsev , N.A. Osik , A.S. Berezin , A.S. Potapov , E.V. Lider

{"title":"Anion influence on the structure and cytotoxicity of Copper(II) complexes based on 2,2’-bipyridine/1,10-phenanthroline and benzimidazole derivative","authors":"Yu.A. Golubeva , E.A. Ermakova , K.S. Smirnova , L.S. Klyushova , N.P. Zaytsev , N.A. Osik , A.S. Berezin , A.S. Potapov , E.V. Lider","doi":"10.1016/j.ica.2025.122803","DOIUrl":null,"url":null,"abstract":"<div><div>Eight new copper(II) coordination compounds have been synthesized by the reactions of Cu(X)2 salts (X = Cl−, Br−, NO3− or ClO4−), 2,2′-bipyridine / 1,10-phenanthroline and 1-(1H-benzimidazol-1-ylmethyl)-1H-1,2,3-benzotriazole (L): [Cu(bipy/phen)LCl2]·H2O (1)/(5), [Cu(bipy/phen)LBr2]·H2O (2)/(6), Cu(bipy)L2(NO3)2(H2O) (3), [Cu(bipy)L2(ClO4)2]·0.4C2H5OH (4), {[Cu(phen)L2(NO3)]NO3·0.5H2O·0.8C2H5OH}n (7), [Cu(phen)L2(MeCN)ClO4]ClO4 (8). The complexes were characterized by CHN, thermogravimetric and high-resolution electrospray mass spectrometric analysis, IR spectroscopy, powder and single-crystal X-ray diffraction. A crystallographic study revealed that Cu:bipy/phen:L ratio, the geometry of the complexes and their nuclearity differ depending on the selected anions. Stability of the complexes in ethanol and phosphate-buffered saline was studied by UV–Vis and EPR spectroscopy. In vitro cytotoxic activity was determined against three tumor cell lines (A549, Hep2, HepG2) and non-tumor lung fibroblasts MRC5. All complexes exhibit dose-dependent cytotoxicity on tumor cells with phenanthroline-based compounds 5–8 being 3–10 times more cytotoxic than medical drug cisplatin.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"587 ","pages":"Article 122803"},"PeriodicalIF":2.7000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0020169325002695","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}

引用次数: 0

Abstract

Eight new copper(II) coordination compounds have been synthesized by the reactions of Cu(X)₂ salts (X = Cl⁻, Br⁻, NO₃⁻ or ClO₄⁻), 2,2′-bipyridine / 1,10-phenanthroline and 1-(1H-benzimidazol-1-ylmethyl)-1H-1,2,3-benzotriazole (L): [Cu(bipy/phen)LCl₂]·H₂O (1)/(5), [Cu(bipy/phen)LBr₂]·H₂O (2)/(6), Cu(bipy)L₂(NO₃)₂(H₂O) (3), [Cu(bipy)L₂(ClO₄)₂]·0.4C₂H₅OH (4), {[Cu(phen)L₂(NO₃)]NO₃·0.5H₂O·0.8C₂H₅OH}_n (7), [Cu(phen)L₂(MeCN)ClO₄]ClO₄ (8). The complexes were characterized by CHN, thermogravimetric and high-resolution electrospray mass spectrometric analysis, IR spectroscopy, powder and single-crystal X-ray diffraction. A crystallographic study revealed that Cu:bipy/phen:L ratio, the geometry of the complexes and their nuclearity differ depending on the selected anions. Stability of the complexes in ethanol and phosphate-buffered saline was studied by UV–Vis and EPR spectroscopy. In vitro cytotoxic activity was determined against three tumor cell lines (A549, Hep2, HepG2) and non-tumor lung fibroblasts MRC5. All complexes exhibit dose-dependent cytotoxicity on tumor cells with phenanthroline-based compounds 5–8 being 3–10 times more cytotoxic than medical drug cisplatin.

查看原文本刊更多论文

阴离子对2,2′-联吡啶/1,10-菲罗啉和苯并咪唑衍生物铜（II）配合物结构和细胞毒性的影响

通过Cu(X)2盐（X = Cl−,Br−，NO3−或ClO4−），2,2′-联吡啶/ 1,10-菲罗啉和1-（1h -苯并咪唑-1-基甲基）- 1h -1,2,3-苯并三唑(L)反应合成了8种新的铜（II）配位化合物：[Cu(bipy/phen)LCl2]·H2O (1)/(5), [Cu(bipy/phen)LBr2]·H2O (2)/(6), Cu(bipy)L2(NO3)2(H2O) (3), [Cu(bipy)L2(ClO4)2]·0.4C2H5OH (4), {[Cu(phen)L2(NO3)]NO3·0.5H2O·0.8C2H5OH}n (7), [Cu(phen)L2(MeCN)ClO4]ClO4(8)。通过CHN、热重和高分辨率电喷雾质谱、红外光谱、粉末和单晶x射线衍射对配合物进行了表征。晶体学研究表明，Cu:bipy/phen:L比、配合物的几何形状和核性质随阴离子的选择而不同。用紫外可见光谱和EPR光谱研究了配合物在乙醇和磷酸盐缓冲盐水中的稳定性。体外测定对三种肿瘤细胞系（A549、Hep2、HepG2）和非肿瘤肺成纤维细胞MRC5的细胞毒活性。所有复合物对肿瘤细胞都表现出剂量依赖性的细胞毒性，其中以菲罗啉为基础的化合物5-8比医用药物顺铂的细胞毒性高3-10倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.