A polygenic risk score is associated with risk of bladder cancer and earlier age of diagnosis, independent of lifestyle factors.

IF 2.3 3区医学 Q3 ONCOLOGY

Urologic Oncology-seminars and Original Investigations Pub Date : 2025-06-05 DOI:10.1016/j.urolonc.2025.05.009

David J Nusbaum, Zhuqing Shi, Annabelle Ashworth, Huy Tran, Jun Wei, Aaron S Dahmen, Piyush K Agarwal, Craig V Labbate, Brian T Helfand, Jianfeng Xu

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引用次数: 0

Abstract

Background: Genetic risk factors are not currently incorporated into the clinical evaluation of patients at risk for bladder cancer (BCa). The objective of this study is to assess the independent and joint effects of genetic and lifestyle factors on the risk of developing BCa and age at diagnosis.

Methods: This is a population-based cohort study of the UK Biobank, consisting of 3,373 BCa cases and 481,275 controls. A polygenic risk score (PGS) was calculated and the effect of lifestyle and genetic factors on BCa risk was estimated using hazard ratio (HR).

Results: The PGS was a significant and independent predictor of the risk of BCa diagnosis. Compared to never-smokers with BMI <30 and a PGS in the lowest decile, current smoking was associated with a HR of 4.47 (95% CI 3.35-5.98) and a PGS in the highest decile was associated with a HR of 4.57 (95% CI 3.44-6.09). Risk was highest for current smokers with BMI ≥30 and a PGS in the highest decile (HR 8.14, 95% CI 4.95-13.36). Most study subjects (∼95%) were of European ancestry.

Conclusion: The PGS was an independent and significant predictor of the risk of BCa and earlier age at diagnosis. The effect size of PGS in the highest decile was similar to that of smoking. Joint effects were observed with smoking status and BMI. These data provide support for incorporating measures of genetic risk factors in efforts to improve early detection of BCa.

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多基因风险评分与膀胱癌风险和早期诊断年龄相关，独立于生活方式因素。

背景：遗传风险因素目前尚未纳入膀胱癌（BCa）风险患者的临床评估。本研究的目的是评估遗传和生活方式因素对BCa发病风险和诊断年龄的独立和共同影响。方法：这是英国生物银行的一项基于人群的队列研究，包括3373例BCa病例和481275例对照。计算多基因风险评分（PGS），使用危险比（HR）评估生活方式和遗传因素对BCa风险的影响。结果：PGS是BCa诊断风险的重要且独立的预测因子。结论：PGS是BCa风险和早期诊断年龄的独立且显著的预测因子。PGS在最高十分位数的效应大小与吸烟相似。观察吸烟状况和BMI的联合效应。这些数据为将遗传风险因素纳入改善BCa早期检测的努力提供了支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urologic Oncology-seminars and Original Investigations 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.70%

发文量

297

审稿时长

7.6 weeks

期刊介绍： Urologic Oncology: Seminars and Original Investigations is the official journal of the Society of Urologic Oncology. The journal publishes practical, timely, and relevant clinical and basic science research articles which address any aspect of urologic oncology. Each issue comprises original research, news and topics, survey articles providing short commentaries on other important articles in the urologic oncology literature, and reviews including an in-depth Seminar examining a specific clinical dilemma. The journal periodically publishes supplement issues devoted to areas of current interest to the urologic oncology community. Articles published are of interest to researchers and the clinicians involved in the practice of urologic oncology including urologists, oncologists, and radiologists.