Electrochemotherapy in the Treatment of Bone Metastases: A Narrative Review.

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

CardioVascular and Interventional Radiology Pub Date : 2025-07-01 Epub Date: 2025-06-06 DOI:10.1007/s00270-025-04077-9

Adlane Feddal, Frédéric Deschamps, Paul Beunon, Thierry De Baère, Lambros Tselikas, Baptiste Bonnet

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引用次数: 0

Abstract

Bone is the third most common site for metastases, frequently leading to skeletal-related events (SREs) such as pain, metastatic epidural spinal cord compression (MESCC), and pathological fractures all of which significantly impact patients' quality of life. In recent years, minimally invasive image-guided therapies have been developed to achieve local tumor control, alleviate pain, and improve functionality, often in conjunction with long-established treatments (chemotherapy, radiation, surgery) and analgesics. Cementoplasty and thermal ablation have demonstrated proven efficacy and safety; however, certain challenging cases remain due to anatomical or tumor-related factors. Innovative techniques such as electrochemotherapy (ECT) are emerging to address these clinical challenges. This review provides an overview of ECT, its role in treatment protocols, and recent data regarding its efficacy in managing bone metastases, with a focus on local control, pain relief, and safety.

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电疗治疗骨转移：一个叙述性的回顾。

骨是第三大最常见的转移部位，经常导致骨骼相关事件（SREs），如疼痛、转移性硬膜外脊髓压迫（MESCC）和病理性骨折，所有这些都会显著影响患者的生活质量。近年来，微创图像引导治疗已经发展到实现局部肿瘤控制，缓解疼痛和改善功能，通常与长期建立的治疗（化疗，放疗，手术）和镇痛药相结合。骨水泥成形术和热消融已经证明了有效性和安全性；然而，由于解剖或肿瘤相关因素，某些具有挑战性的病例仍然存在。创新的技术，如电疗（ECT）正在出现，以解决这些临床挑战。这篇综述提供了电痉挛疗法的概述，它在治疗方案中的作用，以及最近关于它在骨转移治疗中的有效性的数据，重点是局部控制，疼痛缓解和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CardioVascular and Interventional Radiology 医学-核医学

CiteScore

5.50

自引率

13.80%

发文量

306

审稿时长

3-8 weeks

期刊介绍： CardioVascular and Interventional Radiology (CVIR) is the official journal of the Cardiovascular and Interventional Radiological Society of Europe, and is also the official organ of a number of additional distinguished national and international interventional radiological societies. CVIR publishes double blinded peer-reviewed original research work including clinical and laboratory investigations, technical notes, case reports, works in progress, and letters to the editor, as well as review articles, pictorial essays, editorials, and special invited submissions in the field of vascular and interventional radiology. Beside the communication of the latest research results in this field, it is also the aim of CVIR to support continuous medical education. Articles that are accepted for publication are done so with the understanding that they, or their substantive contents, have not been and will not be submitted to any other publication.