Impact of Thyroid Arterial Embolization on Clinical and Biochemical Outcomes and Quality of Life in Patients with Nodular and Multinodular Goiter.

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

CardioVascular and Interventional Radiology Pub Date : 2025-07-01 Epub Date: 2025-06-06 DOI:10.1007/s00270-025-04055-1

Resham Singh, Niraj Nirmal Pandey, Sanjeev Kumar, Om Prakash Prajapati, Kapil Sikka, Priya Jagia

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引用次数: 0

Abstract

Purpose: To assess the safety and efficacy of thyroid arterial embolization (TAE) and its impact on clinical outcomes and quality of life (QoL) in patients with nodular and multinodular goiter (NG/ MNG).

Materials and methods: The study included 20 patients with NG/ MNG (16 women, 4 men; mean age, 37 years) who underwent TAE using polyvinyl alcohol (PVA) particles (350-500 μm) between January 2022 and December 2023. Clinical, radiological and quality of life (QoL) assessment (thyPRO-39 questionnaire) were performed at baseline and 6 months post-procedure. Biochemical evaluation with thyroid function tests were done at 1 week, 1 month, 3 months and 6 months post-procedure.

Results: Of 20 patients, 16 had solitary thyroid nodules (STN), while 4 had multinodular goiter (MNG). Three patients had non-Graves hyperthyroidism, while the remainder were euthyroid. Technical success was achieved in all patients. 35 out of 82 interrogated thyroid arteries were seen supplying the nodules and were successfully embolized using PVA particles. At 6 months follow-up, no major complications were reported. Minor complications, including neck pain (60%), fever (20%), toothache (5%) and arm pain (5%) were seen and responded well to conservative management. The median volume of STN/dominant nodule decreased by 63.7%, from 27.5 ml (13.7-59) to 10 ml (7-17.0) (p < 0.001). Goiter score decreased from 40 (34-78.5) to 17.5 (12.5-31.5), hyperthyroid score from 15.5 (10.5-38.5) to 8 (2-13), cosmetic/ appearance score from 43 (28-51) to 1 (1-21), composite score from 26.1 (21.5-40.9) to 17.6 (14.7-26.1), and QoL score from 25 (25-50) to 0 (0-25); all changes were statistically significant (p < 0.001).

Conclusion: TAE is a safe and effective treatment option in the non-surgical management of benign NG/ MNG, significantly improving these patients' clinical outcome and having a favourable impact on quality of life.

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甲状腺动脉栓塞对结节性和多结节性甲状腺肿患者临床生化结局及生活质量的影响。

目的：评价甲状腺动脉栓塞（TAE）治疗结节性和多结节性甲状腺肿（NG/ MNG）的安全性和有效性及其对临床结局和生活质量（QoL）的影响。材料和方法：纳入NG/ MNG患者20例(女性16例，男性4例；平均年龄37岁)，在2022年1月至2023年12月期间使用聚乙烯醇（PVA）颗粒（350-500 μm）进行TAE。在基线和术后6个月进行临床、放射学和生活质量（QoL）评估（thyPRO-39问卷）。术后1周、1个月、3个月和6个月进行生化评价和甲状腺功能检查。结果：20例患者中单发甲状腺结节（STN） 16例，多结节性甲状腺肿（MNG） 4例。3例为非格雷夫斯甲亢，其余为甲状腺功能正常。所有患者均取得了技术上的成功。82条被询问的甲状腺动脉中有35条供应结节，并成功地使用PVA颗粒栓塞。随访6个月，无重大并发症报告。轻微并发症包括颈部疼痛（60%）、发热（20%）、牙痛（5%）和臂痛（5%），保守治疗效果良好。STN/优势结节的中位体积下降了63.7%，从27.5 ml（13.7-59）降至10 ml (7-17.0) (p)。结论：TAE是良性NG/ MNG非手术治疗中安全有效的治疗选择，显著改善了这些患者的临床预后，并对生活质量产生了良好的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CardioVascular and Interventional Radiology 医学-核医学

CiteScore

5.50

自引率

13.80%

发文量

306

审稿时长

3-8 weeks

期刊介绍： CardioVascular and Interventional Radiology (CVIR) is the official journal of the Cardiovascular and Interventional Radiological Society of Europe, and is also the official organ of a number of additional distinguished national and international interventional radiological societies. CVIR publishes double blinded peer-reviewed original research work including clinical and laboratory investigations, technical notes, case reports, works in progress, and letters to the editor, as well as review articles, pictorial essays, editorials, and special invited submissions in the field of vascular and interventional radiology. Beside the communication of the latest research results in this field, it is also the aim of CVIR to support continuous medical education. Articles that are accepted for publication are done so with the understanding that they, or their substantive contents, have not been and will not be submitted to any other publication.