Preliminary Insights Into the Relationship Between the Gut Microbiome and Host Genome in Posttraumatic Stress Disorder

IF 2.4 4区 心理学 Q2 BEHAVIORAL SCIENCES
Michaela A. O'Hare, Carlien Rust, Stefanie Malan-Müller, Walter Pirovano, Christopher A. Lowry, Matsepo Ramaboli, Leigh L. van den Heuvel, Soraya Seedat, PGC-PTSD Microbiome Workgroup, Sian M. J. Hemmings
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引用次数: 0

Abstract

Posttraumatic stress disorder (PTSD) may develop following trauma exposure; however, not all trauma-exposed individuals develop PTSD, suggesting the presence of susceptibility and resilience factors. The gut microbiome and host genome, which are interconnected, have been implicated in the aetiology of PTSD. However, their interaction has yet to be investigated in a South African population. Using genome-wide genotype data and 16S rRNA (V4) gene amplicon sequencing data from 53 trauma-exposed controls and 74 PTSD cases, we observed no significant association between the host genome and summed abundance of Mitsuokella, Odoribacter, Catenibacterium and Olsenella, previously reported as associated with PTSD status in this cohort. However, PROM2 rs2278067 T-allele was significantly positively associated with the summed relative abundance of these genera, but only in individuals with PTSD and not trauma-exposed controls (p < 0.014). Polygenic risk scores generated using genome-wide association study summary statistics from the PGC-PTSD Overall Freeze 2 were not predictive of gut microbial composition in this cohort. These preliminary results suggest a potential role for the interaction between genetic variation and gut microbial composition in the context of PTSD, underscoring the need for further investigation.

Abstract Image

创伤后应激障碍患者肠道微生物组与宿主基因组关系的初步研究
创伤后应激障碍(PTSD)可能在创伤暴露后发展;然而,并不是所有的创伤暴露个体都会患上PTSD,这表明存在易感性和弹性因素。肠道微生物组和宿主基因组相互关联,与创伤后应激障碍的病因学有关。然而,它们的相互作用尚未在南非人群中进行调查。利用53名创伤暴露对照组和74名创伤后应激障碍患者的全基因组基因型数据和16S rRNA (V4)基因扩增子测序数据,我们观察到宿主基因组与Mitsuokella、Odoribacter、Catenibacterium和Olsenella的总丰度之间没有显著关联,而这些细菌之前被报道与该队列中的创伤后应激障碍状态相关。然而,PROM2 rs2278067 t等位基因与这些属的总相对丰度显著正相关,但仅在PTSD患者而非创伤暴露对照组中(p < 0.014)。使用PGC-PTSD Overall Freeze 2的全基因组关联研究汇总统计数据生成的多基因风险评分不能预测该队列中的肠道微生物组成。这些初步结果表明,在PTSD的背景下,遗传变异和肠道微生物组成之间的相互作用可能起着潜在的作用,强调了进一步研究的必要性。
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来源期刊
Genes Brain and Behavior
Genes Brain and Behavior 医学-行为科学
CiteScore
6.80
自引率
4.00%
发文量
62
审稿时长
4-8 weeks
期刊介绍: Genes, Brain and Behavior was launched in 2002 with the aim of publishing top quality research in behavioral and neural genetics in their broadest sense. The emphasis is on the analysis of the behavioral and neural phenotypes under consideration, the unifying theme being the genetic approach as a tool to increase our understanding of these phenotypes. Genes Brain and Behavior is pleased to offer the following features: 8 issues per year online submissions with first editorial decisions within 3-4 weeks and fast publication at Wiley-Blackwells High visibility through its coverage by PubMed/Medline, Current Contents and other major abstracting and indexing services Inclusion in the Wiley-Blackwell consortial license, extending readership to thousands of international libraries and institutions A large and varied editorial board comprising of international specialists.
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