{"title":"Decoding of the Role of TREM2 in Neuropathic Pain: Molecular Pathway and Neuroinflammatory Mechanism","authors":"Nithya Vijayan, Punniyakoti Veeraveedu Thanikachalam, Saraswati Patel","doi":"10.1002/ddr.70111","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Neuropathic pain is a debilitating condition characterized by chronic pain that is often refractory to conventional treatments. Increasing evidence suggests that microglia, the resident immune cells of the central nervous system, play a crucial role in modulating pain pathways through neuroinflammatory mechanisms. The Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), in conjunction with DNAX-activating protein 12 (DAP12), regulates microglial activation and immune responses, thereby influencing neuropathic pain progression. This review explores the molecular mechanisms by which TREM2 contributes to pain modulation, focusing on its role in microglial activation, cytokine release, oxidative stress, and neuronal sensitization. Furthermore, we discuss the therapeutic potential of targeting TREM2 signaling for neuropathic pain management. Understanding the interplay between TREM2 and neuroinflammation offer novel insights into developing targeted interventions for chronic pain conditions.</p>\n </div>","PeriodicalId":11291,"journal":{"name":"Drug Development Research","volume":"86 4","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Development Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ddr.70111","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Neuropathic pain is a debilitating condition characterized by chronic pain that is often refractory to conventional treatments. Increasing evidence suggests that microglia, the resident immune cells of the central nervous system, play a crucial role in modulating pain pathways through neuroinflammatory mechanisms. The Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), in conjunction with DNAX-activating protein 12 (DAP12), regulates microglial activation and immune responses, thereby influencing neuropathic pain progression. This review explores the molecular mechanisms by which TREM2 contributes to pain modulation, focusing on its role in microglial activation, cytokine release, oxidative stress, and neuronal sensitization. Furthermore, we discuss the therapeutic potential of targeting TREM2 signaling for neuropathic pain management. Understanding the interplay between TREM2 and neuroinflammation offer novel insights into developing targeted interventions for chronic pain conditions.
期刊介绍：
Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, and drug delivery, formulation, and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics, as well as global management, health care policy, and regulatory issues involving the drug discovery and development process. In addition to full-length articles, Drug Development Research publishes Brief Reports on important and timely new research findings, as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes, new technologies, and broad aspects of drug discovery and development.
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