Supplementation of Omega-3 Increases Serum Levels of Brain-Derived Neurotrophic Factor and Decreases Depression Status in Patients With Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

IF 2.9 3区医学 Q3 NUTRITION & DIETETICS

Journal of Human Nutrition and Dietetics Pub Date : 2025-06-08 DOI:10.1111/jhn.70076

Dina Gholipour, Mansour Shahraki, Mansour Shakiba, Ali Shamsi-Goushki

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Abstract

Background

There is a direct relationship between omega-3 and major depression. This study was conducted to investigate the effect of supplementation of omega-3 fatty acids on serum levels of brain-derived neurotrophic factor (BDNF) and depression status in patients with bipolar disorder (BD).

Methods

This double-blind clinical trial was conducted on 60 men with BD. The patients were grouped into two groups and received 2 g/day of omega-3 supplements or a placebo daily for 2 months. The serum concentrations of BDNF and depression scores were investigated before and after the intervention. Afterward, the data were analyzed using the non-parametric Wilcoxon and Mann–Whitney tests.

Results

The supplementation of omega-3 fatty acids significantly increased the serum concentration of BDNF compared to pre-intervention (0.449 ± 0.110 ng/mL vs. 0.756 ± 0.160 ng/mL) and also decreased the scores on the Hamilton test (40.13 ± 9.51 vs. 22.40 ± 7.49) (p < 0.05). The results also showed that supplementation with omega-3 fatty acids significantly increased the serum concentration of BDNF (0.756 ± 0.160 ng/mL vs. 0.504 ± 0.154 ng/mL) and decreased the scores on the Hamilton test compared to the placebo group (22.40 ± 7.49 vs. 29.35 ± 6.08) (p < 0.05).

Conclusions

In conclusion, daily supplementation with 2 g of omega-3 fatty acids for 2 months decreased depression scores and increased serum concentrations of BDNF in BD patients compared to the placebo group.

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补充Omega-3可提高双相情感障碍患者血清脑源性神经营养因子水平并降低抑郁状态：一项随机、双盲、安慰剂对照临床试验

研究背景：omega-3脂肪酸与重度抑郁症之间存在直接关系。本研究旨在探讨补充omega-3脂肪酸对双相情感障碍（BD）患者血清脑源性神经营养因子（BDNF）水平和抑郁状态的影响。方法对60例男性BD患者进行双盲临床试验，将患者分为两组，每天服用2 g/d的omega-3补充剂或安慰剂，连续2个月。观察干预前后血清BDNF浓度及抑郁评分。随后，使用非参数Wilcoxon和Mann-Whitney检验对数据进行分析。结果与干预前相比，补充omega-3脂肪酸显著提高了血清BDNF浓度（0.449±0.110 ng/mL vs. 0.756±0.160 ng/mL），降低了Hamilton测试分数（40.13±9.51 vs. 22.40±7.49）（p < 0.05）。结果还显示，与安慰剂组相比，补充omega-3脂肪酸显著提高了血清BDNF浓度（0.756±0.160 ng/mL vs. 0.504±0.154 ng/mL），降低了Hamilton测试分数（22.40±7.49 vs. 29.35±6.08）（p < 0.05）。总之，与安慰剂组相比，每天补充2 g ω -3脂肪酸2个月可降低BD患者的抑郁评分，并增加血清BDNF浓度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Human Nutrition and Dietetics 医学-营养学

CiteScore

5.30

自引率

15.20%

发文量

133

审稿时长

6-12 weeks

期刊介绍： Journal of Human Nutrition and Dietetics is an international peer-reviewed journal publishing papers in applied nutrition and dietetics. Papers are therefore welcomed on: - Clinical nutrition and the practice of therapeutic dietetics - Clinical and professional guidelines - Public health nutrition and nutritional epidemiology - Dietary surveys and dietary assessment methodology - Health promotion and intervention studies and their effectiveness - Obesity, weight control and body composition - Research on psychological determinants of healthy and unhealthy eating behaviour. Focus can for example be on attitudes, brain correlates of food reward processing, social influences, impulsivity, cognitive control, cognitive processes, dieting, psychological treatments. - Appetite, Food intake and nutritional status - Nutrigenomics and molecular nutrition - The journal does not publish animal research The journal is published in an online-only format. No printed issue of this title will be produced but authors will still be able to order offprints of their own articles.