Association of fentanyl test strip results and change in drug use behaviors: A multi-state, community-based observational study

IF 4.4 2区医学 Q1 SUBSTANCE ABUSE

International Journal of Drug Policy Pub Date : 2025-06-09 DOI:10.1016/j.drugpo.2025.104867

Kitty H. Gelberg , Nabila El-Bassel , Denise C. Babineau , Rachel A. Vickers-Smith , Laura C. Fanucchi , Janet E. Childerhose , Megan E. Hall , Megan E. Dzurec , Jennifer Villani , Mary R. Russo , Patricia LeBaron , Katherine R. Marks , Kathyrn E. Lancaster , Louisa Gilbert , James L. David , Barry S. Eggleston , Carter A. Roeber , Emmanuel A. Oga , Redonna K. Chandler , Sharon L. Walsh

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引用次数: 0

Abstract

Background

The Stay Safe Study, conducted between May and December 2023 in the United States, investigated the association between fentanyl test strip (FTS) use and risk reduction behaviors. This paper examines the association between self-reported FTS results and change in drug use behaviors.

Methods

We solicited self-reported drug and FTS use among people who use drugs (PWUD), with a baseline and four weekly surveys over a 28-day observation period in three states (Kentucky, New York and Ohio). For each day participants reported drug use, they were asked types of drugs used, use of FTS, FTS results, and 12 drug use behavior changes because of the result. A generalized estimating equation approach was used to model associations between FTS results and each outcome.

Results

These analyses included 541 PWUD who used FTS at least once in the observation period. Positive FTS results were associated with participants taking turns, having naloxone nearby, and using less drugs. There was a four-fold reduction in the amount of drugs used following a positive FTS result (odds ratio (OR)=4.37; 95 % CI, 3.45–5.55). This was modified by self-reported types of drugs tested, with a 20-fold reduction when testing illicit benzodiazepines (OR=19.92; 95 % CI, 8.6–46.27), a 10-fold reduction when testing illicit stimulants (OR=10.04; 95 % CI, 6.49–15.53), and 2-fold reduction in drugs used when testing illicit opioids or other drugs tested (OR=2.11; 95 % CI, 1.14–3.92).

Conclusions

These findings suggest that FTS assist PWUD to immediately reduce their risks by changing drug use behaviors, including reducing the amount of drug used.

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芬太尼试纸结果与药物使用行为改变的关联：一项多州、基于社区的观察性研究

2023年5月至12月在美国进行的“保持安全”研究调查了芬太尼试纸（FTS）使用与降低风险行为之间的关系。本文探讨了自我报告的FTS结果与药物使用行为改变之间的关系。方法：我们在三个州（肯塔基州、纽约州和俄亥俄州）收集吸毒者（PWUD）的自我报告药物和FTS使用情况，并在28天的观察期内进行基线调查和每周4次调查。参与者每天报告药物使用情况，他们被问及使用的药物类型，FTS的使用情况，FTS的结果，以及由于结果而导致的12种药物使用行为改变。采用广义估计方程方法对FTS结果与各结局之间的关联进行建模。结果541例PWUD患者在观察期内至少使用过一次FTS。FTS阳性结果与参与者轮流服用、附近服用纳洛酮和较少使用药物有关。FTS阳性结果后，药物使用量减少了4倍(优势比(OR)=4.37；95% ci, 3.45-5.55)。自我报告的测试药物类型改变了这一点，当测试非法苯二氮卓类药物时，减少了20倍(OR=19.92；95% CI, 8.6-46.27)，在检测非法兴奋剂时减少了10倍(OR=10.04；95% CI, 6.49-15.53)，在检测非法阿片类药物或其他被检测药物时，使用的药物减少了2倍(or =2.11；95% ci, 1.14-3.92)。结论FTS可通过改变药物使用行为，包括减少药物使用量，帮助puwud患者立即降低用药风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Drug Policy SUBSTANCE ABUSE-

CiteScore

7.80

自引率

11.40%

发文量

307

审稿时长

62 days

期刊介绍： The International Journal of Drug Policy provides a forum for the dissemination of current research, reviews, debate, and critical analysis on drug use and drug policy in a global context. It seeks to publish material on the social, political, legal, and health contexts of psychoactive substance use, both licit and illicit. The journal is particularly concerned to explore the effects of drug policy and practice on drug-using behaviour and its health and social consequences. It is the policy of the journal to represent a wide range of material on drug-related matters from around the world.