Immunomodulatory effects of 4-hydroxynonenal

IF 10.7 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Redox Biology Pub Date : 2025-06-06 DOI:10.1016/j.redox.2025.103719

Melina Ioannidis , Johanna Tjepkema , Michael R.P. Uitbeijerse , Geert van den Bogaart

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Abstract

The reactive aldehyde 4-hydroxy-2-nonenal (4-HNE) is a byproduct of lipid peroxidation driven by reactive oxygen species (ROS). 4-HNE covalently binds to macromolecules such as proteins, altering their functions. While 4-HNE is implicated in various ROS-related pathologies, its impact on the immune system remains incompletely understood. This review explores how 4-HNE influences molecular mechanisms involved in inflammation and immune cell functions. 4-HNE modulates inflammation through the interaction with several signaling pathways, including nuclear factor kappa-light-chain enhancement of activated B cells (NF-κB), nuclear factor erythroid 2-related factor (Nrf2), mitogen-activated protein kinases (MAPK), toll-like receptor (TLR) 4, and stimulator of interferon genes (STING), thereby affecting immune responses and modulating cytokine production and inflammasome activation. However, its effects are complex, exhibiting both pro- and anti-inflammatory properties depending on dose and cell type. This review highlights the multiple mechanisms by which 4-HNE modulates the immune cells' responses.

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4-羟基壬烯醛的免疫调节作用

活性醛4-羟基-2-壬烯醛（4-HNE）是由活性氧（ROS）驱动的脂质过氧化反应的副产物。4-HNE与蛋白质等大分子共价结合，改变其功能。虽然4-HNE与各种ros相关病理有关，但其对免疫系统的影响仍不完全清楚。本文综述了4-HNE如何影响炎症和免疫细胞功能的分子机制。4- hne通过与活化B细胞的核因子κB轻链增强（NF-κB）、核因子红细胞2相关因子（Nrf2）、丝裂原活化蛋白激酶（MAPK）、toll样受体（TLR） 4和干扰素基因刺激因子（STING）等多种信号通路相互作用调节炎症，从而影响免疫应答，调节细胞因子的产生和炎症小体的活化。然而，其作用是复杂的，根据剂量和细胞类型表现出促炎和抗炎特性。这篇综述强调了4-HNE调节免疫细胞反应的多种机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Redox Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

19.90

自引率

3.50%

发文量

318

审稿时长

25 days

期刊介绍： Redox Biology is the official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe. It is also affiliated with the International Society for Free Radical Research (SFRRI). This journal serves as a platform for publishing pioneering research, innovative methods, and comprehensive review articles in the field of redox biology, encompassing both health and disease. Redox Biology welcomes various forms of contributions, including research articles (short or full communications), methods, mini-reviews, and commentaries. Through its diverse range of published content, Redox Biology aims to foster advancements and insights in the understanding of redox biology and its implications.