[New treatments for cutaneous lupus].

La Revue du praticien Pub Date : 2025-02-01
François Chasset
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Abstract

NEW TREATMENTS FOR CUTANEOUS LUPUS. Cutaneous lupus may present as an isolated skin disease, or may be associated with systemic lupus, of which it is one of the most frequent manifestations. The management of this disease is poorly codified, and treatment depends on the severity of the disease, whether or not it is associated with systemic lupus, and many other factors. Synthetic antimalarials, in particular hydroxychloroquine, are the cornerstone of treatment. In recent years, several molecules have shown results that are both highly promising and disappointing. A major new development is the granting of European marketing authorization for anifrolumab in systemic lupus in 2022, which seems to be producing particularly interesting results in skin involvement.

[皮肤红斑狼疮的新疗法]。
皮肤红斑狼疮的新疗法。皮肤红斑狼疮可能是一种孤立的皮肤病,也可能与系统性红斑狼疮有关,这是最常见的表现之一。这种疾病的管理编纂得很差,治疗取决于疾病的严重程度,是否与系统性狼疮有关,以及许多其他因素。合成抗疟药,特别是羟氯喹,是治疗的基石。近年来,一些分子的研究结果既充满希望,又令人失望。一个重要的新进展是,anfrolumab在2022年获得了系统性狼疮的欧洲上市许可,该药物似乎在皮肤病变方面产生了特别有趣的结果。
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