Polymorphism rs259983 of the ZNF831 gene is associated with the risk of anemia in pregnant women with gestational diabetes.

The Egyptian journal of medical human genetics Pub Date : 2025-01-01 Epub Date: 2025-06-03 DOI:10.1186/s43042-025-00723-6

Nataliia Karpova, Olga Dmitrenko, Ekaterina Arshinova, Malik Nurbekov

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Abstract

Background: Iron deficiency is a cause of anemia in pregnant women. Iron metabolism is closely related to zinc levels and the state of zinc-containing proteins. Zinc-binding proteins (ZNFs) can also bind other metal ions. Genetic factors can also be a factor leading to unstable iron levels in the blood.

Results: The aim of this study was to investigate the relationship between rs259983 of the zinc finger protein 831 (ZNF831) gene and anemia in pregnant women with gestational diabetes mellitus (GDM). The PCR test system with Taq-Man samples was developed for genotyping rs259983 of the ZNF831 gene. As a result, an association was found between rs259983 of the ZNF831 gene and the risk of anemia. According to in silico analysis, the ZNF831 protein is able to bind iron (FE, 0.69) and other ions, which may play an essential role in anemia pathogenesis.

Conclusions: Carriers of the C allele in the homozygous state rs259983 of the ZNF831 are at greater risk of developing anemia. Further studies are required to assess the effect of ZNF831 polymorphisms on the risk of pregnancy pathologies.

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ZNF831基因rs259983多态性与妊娠期糖尿病孕妇贫血风险相关

背景：缺铁是孕妇贫血的一个原因。铁代谢与锌水平和含锌蛋白状态密切相关。锌结合蛋白（ZNFs）也可以结合其他金属离子。遗传因素也可能是导致血液中铁含量不稳定的一个因素。结果：本研究旨在探讨锌指蛋白831 （ZNF831）基因rs259983与妊娠期糖尿病（GDM）孕妇贫血的关系。建立了Taq-Man样品PCR检测系统，对ZNF831基因rs259983进行分型。结果发现，ZNF831基因的rs259983与贫血风险之间存在关联。根据硅分析，ZNF831蛋白能够结合铁（FE, 0.69）等离子，可能在贫血发病中发挥重要作用。结论：ZNF831基因纯合子状态rs259983的C等位基因携带者患贫血的风险更高。需要进一步的研究来评估ZNF831多态性对妊娠病理风险的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Egyptian journal of medical human genetics

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