30 YEARS OF BONE GIANT CELL TUMOR IN THE KNEE: A BRAZILIAN PERSPECTIVE.

IF 0.5 4区医学 Q4 ORTHOPEDICS

Acta Ortopedica Brasileira Pub Date : 2025-06-02 eCollection Date: 2025-01-01 DOI:10.1590/1413-785220253302e285061

Eduardo da Silva Rodrigues, Michelle Ghert, Bruno Pereira Antunes, Carlos Roberto Galia, Julie Francine Cerutti Santos Pestilho, Eduardo Areas Toller, Olavo Pires de Camargo, Edgard Eduard Engel, Suely Akiko Nakagawa, Alex Guedes, Ricardo Gehrke Becker

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Abstract

Objective: To analyze the evolution of patient/tumor characteristics and treatments for GCTB in the knee in Brazil over 30 years and assess changes in local recurrence rates.

Methods: Retrospective study of 335 patients (1989-2021) from 16 Brazilian centers. Data on patient/tumor characteristics, recurrence, metastasis, and treatment trends were evaluated.

Results: Campanacci grade 3 tumors, pulmonary metastasis, and local recurrence rates were 56.7%, 5.3%, and 15.8%, respectively. Recurrence was 21.4% for curettage and 9% for resection. Curettage with denosumab showed 23.8% recurrence, versus 21% for curettage alone. Overall, local recurrence decreased from 22.9% (1989-2005) to 15.1% (2006-2021), with a significant drop after en bloc resection (23% to 7.8%), while curettage-related recurrence remained stable.

Conclusions: Despite an increase in aggressive tumors, local recurrence decreased, especially after en bloc resection. These findings emphasize the challenges of managing rare diseases in emerging economies. Level of evidence: III; Retrospective Cohort Study.

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30年的骨巨细胞瘤在膝盖：巴西的观点。

目的：分析30年来巴西膝关节GCTB患者/肿瘤特征和治疗方法的演变，并评估局部复发率的变化。方法：对来自巴西16个中心的335例患者（1989-2021）进行回顾性研究。评估了患者/肿瘤特征、复发、转移和治疗趋势的数据。结果：Campanacci 3级肿瘤、肺转移和局部复发率分别为56.7%、5.3%和15.8%。刮除复发率为21.4%，切除复发率为9%。denosumab刮除组复发率为23.8%，而单独刮除组为21%。总体而言，局部复发率从22.9%（1989-2005）下降到15.1%(2006-2021)，整体切除后显著下降（23%至7.8%），而刮除相关复发率保持稳定。结论：尽管侵袭性肿瘤增加，但局部复发率下降，特别是在整体切除后。这些发现强调了新兴经济体管理罕见病的挑战。证据等级：III；回顾性队列研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ortopedica Brasileira Orthopedics-

CiteScore

0.90

自引率

14.30%

发文量

审稿时长

25 weeks

期刊介绍： A Revista Acta Ortopédica Brasileira, órgão oficial do Departamento de Ortopedia e Traumatologia da Faculdade de Medicina da Universidade de São Paulo (DOT/FMUSP), é publicada bimestralmente em seis edições ao ano (jan/fev, mar/abr, maio/jun, jul/ago, set/out e nov/dez) com versão em inglês disponível nos principais indexadores nacionais e internacionais e instituições de ensino do Brasil. Sendo hoje reconhecidamente uma importante contribuição para os especialistas da área com sua seriedade e árduo trabalho para as indexações já conquistadas.