Effect of gold nanoparticles in radiation therapy of breast tumor: photon, electron, proton, neutron, helium, and carbon ions irradiation.

IF 1.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Murat Aygün, Zeynep Aygün
{"title":"Effect of gold nanoparticles in radiation therapy of breast tumor: photon, electron, proton, neutron, helium, and carbon ions irradiation.","authors":"Murat Aygün, Zeynep Aygün","doi":"10.1007/s12194-025-00919-w","DOIUrl":null,"url":null,"abstract":"<p><p>It becomes an important issue to enhance the efficacy of radiotherapy in the treatment of solid tumors. This study aims to study the effect of gold nanoparticles on the breast tumor to evaluate in radiation therapy treatment and researches. For this, photon, charged particles (electron, proton, helium, and carbon ions) and neutron interaction parameters of the breast tumor at different incident energies are investigated using PHITS, SRIM Monte Carlo, Phy-X/PSD, ESTAR, and PAGEX softwares. The mass attenuation coefficient, linear attenuation coefficient, effective atomic number, buildup factors, Kerma, mass stoping power, radiation yield, range, half value layer, and mean free path of the breast without and with the gold nanoparticles are calculated and for meaningful evaluation mass attenuation coefficients are compared with Phy-X/PSD results. This comparison shows a good agreement, with all calculated values deviating less than 1.5%. The addition of Au resulted in an enhancement for the radiation absorption ability of the samples. The results present that the radiation absorption effect of breast tumor with gold nanoparticles is higher than the case without gold nanoparticles and increase with increasing rates of the gold nanoparticles. This study represents the first comprehensive investigation of charged, uncharged particles, and photons, as well as different gold nanoparticles ratios, conducted concurrently. The findings may lead to the advancement of more effective radiotherapy processes for treatments.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiological Physics and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12194-025-00919-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

It becomes an important issue to enhance the efficacy of radiotherapy in the treatment of solid tumors. This study aims to study the effect of gold nanoparticles on the breast tumor to evaluate in radiation therapy treatment and researches. For this, photon, charged particles (electron, proton, helium, and carbon ions) and neutron interaction parameters of the breast tumor at different incident energies are investigated using PHITS, SRIM Monte Carlo, Phy-X/PSD, ESTAR, and PAGEX softwares. The mass attenuation coefficient, linear attenuation coefficient, effective atomic number, buildup factors, Kerma, mass stoping power, radiation yield, range, half value layer, and mean free path of the breast without and with the gold nanoparticles are calculated and for meaningful evaluation mass attenuation coefficients are compared with Phy-X/PSD results. This comparison shows a good agreement, with all calculated values deviating less than 1.5%. The addition of Au resulted in an enhancement for the radiation absorption ability of the samples. The results present that the radiation absorption effect of breast tumor with gold nanoparticles is higher than the case without gold nanoparticles and increase with increasing rates of the gold nanoparticles. This study represents the first comprehensive investigation of charged, uncharged particles, and photons, as well as different gold nanoparticles ratios, conducted concurrently. The findings may lead to the advancement of more effective radiotherapy processes for treatments.

金纳米粒子在乳腺肿瘤放射治疗中的作用:光子、电子、质子、中子、氦和碳离子照射。
提高放射治疗在实体瘤治疗中的疗效已成为一个重要课题。本研究旨在研究金纳米颗粒对乳腺肿瘤的影响,以评价其在放疗治疗和研究中的应用价值。为此,利用PHITS、SRIM蒙特卡罗、Phy-X/PSD、ESTAR和PAGEX等软件,研究了不同入射能量下乳腺肿瘤的光子、带电粒子(电子、质子、氦和碳离子)和中子相互作用参数。计算了无金纳米粒子和含金纳米粒子的质量衰减系数、线性衰减系数、有效原子数、堆积因子、Kerma、质量回采功率、辐射产率、范围、半值层和平均自由程,并将质量衰减系数与Phy-X/PSD结果进行了比较,对质量衰减系数进行了有意义的评价。这种比较显示出很好的一致性,所有计算值的偏差小于1.5%。金的加入使样品的辐射吸收能力增强。结果表明,纳米金对乳腺肿瘤的辐射吸收效果明显高于未加纳米金的乳腺肿瘤,并随纳米金用量的增加而增强。这项研究代表了首次对带电、非带电粒子和光子以及不同金纳米颗粒比例进行的综合研究。这一发现可能会导致更有效的放射治疗方法的进步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Radiological Physics and Technology
Radiological Physics and Technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
3.00
自引率
12.50%
发文量
40
期刊介绍: The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信