The Relationship Between Heart Rate and Mortality Risk in Patients With Acute Aortic Dissection: A Meta-Analysis.

IF 1.9 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Reviews in cardiovascular medicine Pub Date : 2025-05-27 eCollection Date: 2025-05-01 DOI:10.31083/RCM27755

Tianyi Wang, Lin Sun, Zhaozhuo Niu, Jixian Wang, Yuanshan Wang

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引用次数: 0

Abstract

Background: Acute aortic dissection (AAD) is a rare but life-threatening disease, and its rapid and correct diagnosis is important. Heart rate (HR) is a risk factor for death in patients with AAD, but their relationship remains unknown. This meta-analysis aimed to evaluate whether there was a significant correlation between HR and AAD mortality risk.

Methods: By searching PubMed, Embase, and Web of Science databases, the studies reporting the correlation between HR and AAD were obtained, and their methodological quality was evaluated. Relative risk (RR) with 95% confidence interval (CI) was used as the effect size. Subgroup analysis, sensitivity analysis, and publication bias test (Egger's test and funnel chart) were used to find the source of heterogeneity and evaluate the stability of the results.

Results: Ten studies enrolling >4000 patients were included. Increased HR was positively correlated with increased AAD mortality risk (RR [95% CI] = 1.04 [1.01-1.07], p = 0.006). There was significant statistical heterogeneity among the included studies. The timing of HR monitoring, AAD type, and follow-up time were sources of heterogeneity. Sensitivity analysis showed that the combined results were stable. There was a significant publication bias in the included studies; however, the shear-fill method showed that the publication bias had little effect on the combined results (RR [95% CI] = 1.038 [1.010-1.066], p = 0.008).

Conclusions: There was a positive relationship between increased HR and increased AAD mortality.

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急性主动脉夹层患者心率与死亡风险的关系：一项荟萃分析

背景：急性主动脉夹层（AAD）是一种罕见但危及生命的疾病，其快速正确诊断至关重要。心率（HR）是AAD患者死亡的一个危险因素，但它们之间的关系尚不清楚。本荟萃分析旨在评估HR与AAD死亡风险之间是否存在显著相关性。方法：通过检索PubMed、Embase和Web of Science数据库，获取报告HR与AAD相关性的研究，并对其方法学质量进行评价。采用相对危险度（RR）和95%置信区间（CI）作为效应量。采用亚组分析、敏感性分析和发表偏倚检验（Egger’s检验和漏斗图）寻找异质性来源，评价结果的稳定性。结果：纳入了10项研究，共纳入bb104000例患者。HR升高与AAD死亡风险升高呈正相关（RR [95% CI] = 1.04 [1.01-1.07], p = 0.006）。纳入的研究之间存在显著的统计学异质性。HR监测时间、AAD类型和随访时间是异质性的来源。敏感性分析表明，联合结果是稳定的。纳入的研究存在显著的发表偏倚；但剪切填充法显示，发表偏倚对合并结果影响不大（RR [95% CI] = 1.038 [1.010-1.066], p = 0.008）。结论：HR升高与AAD死亡率升高呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews in cardiovascular medicine 医学-心血管系统

CiteScore

2.70

自引率

3.70%

发文量

377

审稿时长

1 months

期刊介绍： RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.