Relationship Between Carotid Intraplaque Neovascularization and Immune-Inflammatory Biomarkers with Coronary Stenosis.

IF 1.9 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Reviews in cardiovascular medicine Pub Date : 2025-05-23 eCollection Date: 2025-05-01 DOI:10.31083/RCM28171

Yixue Wang, Jinhong Chen, Xuemin Li, Xinyu Tang, Yu Zhang, Xiao Yang

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引用次数: 0

Abstract

Background: Intraplaque neovascularization (IPN) correlates significantly with plaque vulnerability and can be detected using Angio PLanewave UltraSensitive imaging technology (Angio PL.U.S.; AP). Several immune-inflammatory biomarkers that reflect the state of inflammation and immune homeostasis in the body are currently used to assess cardiovascular and cerebrovascular diseases. This study aimed to investigate the correlation between carotid IPN scores and several immune-inflammatory indicators in patients with different degrees of coronary artery stenosis.

Methods: This study prospectively enrolled 107 patients with coronary artery stenosis confirmed by coronary angiography (CAG). Preoperative ultrasonography was performed to screen for carotid plaques, and AP was conducted to determine whether IPN was present and correctly scored. The levels of immune-inflammatory indicators, plaques, and coronary artery lesions between groups with and without IPN and different IPN scores were analyzed. We utilized logistic regression models to determine the independent predictors of IPN and constructed receiver operating characteristic (ROC) curves. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

Results: Differences in systemic immune inflammation index (SII) levels and plaque thicknesses were found between the groups with and without IPN and between different IPN scores (p < 0.05). The IPN scores were positively correlated with SII levels (r = 0.268, p = 0.005), plaque thickness (r = 0.273, p = 0.005), and Gensini score (r = 0.446, p < 0.001). SII levels (per 10-unit increase) (OR = 1.031) and plaque thickness (OR = 1.897) were independent risk factors for IPN. When the SII was 541 × 10⁹/L and the thickness of the plaque was 2.25 mm, the area under the curve (AUC) was 0.653 and 0.656, respectively. The AUC of the combined diagnosis was 0.711.

Conclusion: Elevated SII levels and increased plaque thickness were associated with the vulnerability of carotid plaques in patients with coronary artery stenosis and may signal increased coronary artery stenosis.

The clinical trial registration: ChiCTR2400094458, https://www.chictr.org.cn/hvshowprojectEN.html?id=266292&v=1.0.

查看原文本刊更多论文

颈动脉斑块内新生血管与冠状动脉狭窄免疫炎症生物标志物的关系

背景：斑块内新生血管（IPN）与斑块易感性显著相关，可通过Angio PLanewave超敏成像技术(Angio pl . us；美联社)。几种反映体内炎症状态和免疫稳态的免疫炎症生物标志物目前被用于评估心脑血管疾病。本研究旨在探讨不同冠状动脉狭窄程度患者颈动脉IPN评分与多项免疫炎症指标的相关性。方法：本研究前瞻性纳入107例经冠状动脉造影（CAG）证实的冠状动脉狭窄患者。术前行超声检查筛查颈动脉斑块，行AP检查判断IPN是否存在并正确评分。分析有IPN组和无IPN组以及不同IPN评分之间的免疫炎症指标、斑块和冠状动脉病变水平。采用logistic回归模型确定IPN的独立预测因子，并构建受试者工作特征（ROC）曲线。计算比值比（ORs）和95%置信区间（ci）。结果：有无IPN组及不同IPN评分组间全身免疫炎症指数（SII）水平及斑块厚度差异有统计学意义（p < 0.05）。IPN评分与SII水平（r = 0.268, p = 0.005）、斑块厚度（r = 0.273, p = 0.005）、Gensini评分（r = 0.446, p < 0.001）呈正相关。SII水平（每增加10个单位）（OR = 1.031）和斑块厚度（OR = 1.897）是IPN的独立危险因素。当SII为541 × 109/L，斑块厚度为2.25 mm时，曲线下面积（AUC）分别为0.653和0.656。联合诊断的AUC为0.711。结论：SII水平升高和斑块厚度增加与冠状动脉狭窄患者颈动脉斑块易损性相关，可能是冠状动脉狭窄加重的信号。临床试验注册：ChiCTR2400094458， https://www.chictr.org.cn/hvshowprojectEN.html?id=266292&v=1.0。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews in cardiovascular medicine 医学-心血管系统

CiteScore

2.70

自引率

3.70%

发文量

377

审稿时长

1 months

期刊介绍： RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.