Osahon Asowata, Ifeoluwa Bodunde, Akinkunmi Okekunle, Onoja M Akpa, David Kadan Danladi, Adekunle Gregory Fakunle, Morenikeji A Komolafe, Reginald Obiako, Kolawole Wahab, Joshua Akinyemi, Albert Akpalu, Olayinka Adebajo, Kelechukwu Uwanuruochi, Samuel Olowookere, Oyedunni Arulogun, Arti Singh, Paul Olowoyo, Oladotun Olalusi, Godwin Inalegwu Ogbole, Ganiyu Adeniyi Amusa, Sunday Adeniyi, Innocent Ijezie Chukwuonye, Okechukwu Ogah, Suleiman Y Isah, Phillip O Ibinaiye, Ayodipupo Oguntade, Eunice Olabinri, Adebolajo Adeyemo, Olayemi Balogun, Benedict Calys-Tagoe, Philip Adebayo, Lambert Appiah, Abiodun Ajose, Ayo Ogunmodede, Abiodun Adeoye, Vincent Shindali, Hamzat Bello, Atinuke M Agunloye, Ugochukwu Onyenonoro, Taiwo Olunuga, Richard Efidi, Oladimeji Adebayo, Musbahu Rabiu, Julius Adesina, Wisdom Oguike, Ayomide Owolabi, Fred Stephen Sarfo, Rufus Akinyemi, Bruce Ovbiagele, Mayowa Owolabi
{"title":"Low Vegetable Consumption doubles the odds of Stroke among people with Hypertension: findings from the SIREN Study in West Africa.","authors":"Osahon Asowata, Ifeoluwa Bodunde, Akinkunmi Okekunle, Onoja M Akpa, David Kadan Danladi, Adekunle Gregory Fakunle, Morenikeji A Komolafe, Reginald Obiako, Kolawole Wahab, Joshua Akinyemi, Albert Akpalu, Olayinka Adebajo, Kelechukwu Uwanuruochi, Samuel Olowookere, Oyedunni Arulogun, Arti Singh, Paul Olowoyo, Oladotun Olalusi, Godwin Inalegwu Ogbole, Ganiyu Adeniyi Amusa, Sunday Adeniyi, Innocent Ijezie Chukwuonye, Okechukwu Ogah, Suleiman Y Isah, Phillip O Ibinaiye, Ayodipupo Oguntade, Eunice Olabinri, Adebolajo Adeyemo, Olayemi Balogun, Benedict Calys-Tagoe, Philip Adebayo, Lambert Appiah, Abiodun Ajose, Ayo Ogunmodede, Abiodun Adeoye, Vincent Shindali, Hamzat Bello, Atinuke M Agunloye, Ugochukwu Onyenonoro, Taiwo Olunuga, Richard Efidi, Oladimeji Adebayo, Musbahu Rabiu, Julius Adesina, Wisdom Oguike, Ayomide Owolabi, Fred Stephen Sarfo, Rufus Akinyemi, Bruce Ovbiagele, Mayowa Owolabi","doi":"10.1177/17474930251349474","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>While hypertension is a primary risk factor, adequate vegetable consumption has been linked with a lower stroke risk. However, it is unclear whether low/inadequate vegetable consumption could aggravate the odds of stroke among people with hypertension. This study assessed the interaction of low vegetable consumption and hypertension with stroke among West Africans.</p><p><strong>Methods: </strong>In this case-control study, 3684 stroke cases (aged ≥18 years) matched for age ±5 years, sex, and ethnicity, with 3684 healthy controls recruited across 15 hospital sites in Nigeria and Ghana. Hypertension was defined using standard guidelines, and vegetable consumption was assessed with a food frequency questionnaire. Multivariable-adjusted conditional logistic regression and interaction model were used to estimate the odds ratios (OR) with a 95% confidence interval (CI) and the synergistic interaction of both low vegetable consumption (< 6 servings per week) and hypertension. The attributable proportion (AP), relative excess risk due to interaction (RERI), and synergy index (SI) were estimated at a two-sided P < 0.05.</p><p><strong>Results: </strong>Overall, the mean age was 59.0±14.9 years, and 45.8%(3376) were female. Among stroke cases, the prevalence of low vegetable consumption and hypertension was 68.1%(2508) and 95.9%(3480), respectively. The multivariable-adjusted odds of stroke, given low vegetable consumption with hypertension, was OR: 25.66 (95%CI: 16.65, 39.54) with a RERI of 13.40 (95%CI: 7.21, 19.59), AP of 0.52 (95%CI: 0.44, 0.60), SI of 2.19 (95%CI: 1.82, 2.63), and a multiplicative interaction of about 50%; 1.51 (95%CI: 0.91, 2.49).</p><p><strong>Conclusion: </strong>The odds of stroke double with low vegetable consumption among people with hypertension in this population.</p>","PeriodicalId":14442,"journal":{"name":"International Journal of Stroke","volume":" ","pages":"17474930251349474"},"PeriodicalIF":6.3000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Stroke","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/17474930251349474","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: While hypertension is a primary risk factor, adequate vegetable consumption has been linked with a lower stroke risk. However, it is unclear whether low/inadequate vegetable consumption could aggravate the odds of stroke among people with hypertension. This study assessed the interaction of low vegetable consumption and hypertension with stroke among West Africans.
Methods: In this case-control study, 3684 stroke cases (aged ≥18 years) matched for age ±5 years, sex, and ethnicity, with 3684 healthy controls recruited across 15 hospital sites in Nigeria and Ghana. Hypertension was defined using standard guidelines, and vegetable consumption was assessed with a food frequency questionnaire. Multivariable-adjusted conditional logistic regression and interaction model were used to estimate the odds ratios (OR) with a 95% confidence interval (CI) and the synergistic interaction of both low vegetable consumption (< 6 servings per week) and hypertension. The attributable proportion (AP), relative excess risk due to interaction (RERI), and synergy index (SI) were estimated at a two-sided P < 0.05.
Results: Overall, the mean age was 59.0±14.9 years, and 45.8%(3376) were female. Among stroke cases, the prevalence of low vegetable consumption and hypertension was 68.1%(2508) and 95.9%(3480), respectively. The multivariable-adjusted odds of stroke, given low vegetable consumption with hypertension, was OR: 25.66 (95%CI: 16.65, 39.54) with a RERI of 13.40 (95%CI: 7.21, 19.59), AP of 0.52 (95%CI: 0.44, 0.60), SI of 2.19 (95%CI: 1.82, 2.63), and a multiplicative interaction of about 50%; 1.51 (95%CI: 0.91, 2.49).
Conclusion: The odds of stroke double with low vegetable consumption among people with hypertension in this population.
期刊介绍:
The International Journal of Stroke is a welcome addition to the international stroke journal landscape in that it concentrates on the clinical aspects of stroke with basic science contributions in areas of clinical interest. Reviews of current topics are broadly based to encompass not only recent advances of global interest but also those which may be more important in certain regions and the journal regularly features items of news interest from all parts of the world. To facilitate the international nature of the journal, our Associate Editors from Europe, Asia, North America and South America coordinate segments of the journal.