André Santos, David Pires, Vanda Marques, Nicole Alesina, Elisa Herraez, Pavel Roudnický, Pedro Rodrigues, Ana Godinho-Santos, Ana Bravo, Catarina Gouveia, Susana Saraiva, Luís Correia, Ricardo Crespo, João da Silva, Marília Cravo, David Potesil, Zbyněk Zdráhal, Jesus Banales, Jose Marin, Joana Torres, Cecília Rodrigues
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引用次数: 0
Abstract
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with underlying inflammatory bowel disease (IBD). This study investigates how PSC predisposes altered inflammatory immune responses and compared to IBD alone. A case-control study was conducted with a cohort of 75 patients, including 16 with PSC (14 with concomitant IBD), 39 with IBD alone, and 20 controls. Serum bile acid profile, proteomic analysis, and immune-related gene expression in colon tissue were examined. Colonic tissue from PSC patients exhibited upregulation of immune regulation and inflammatory signaling mRNA markers, including LGR5, IL-8, CCL2, COX2, TWIST1, and SNAIL. Additionally, PSC patients displayed a distinct proinflammatory serum proteomic signature and moderate elevation of some bile acids, such as glycochenodeoxycholic acid (GCDCA). Co-incubation of human-derived monocytes with GCDCA partially replicated the inflammatory profile observed in PSC. These findings suggest that circulating bile acids modulate peripheral immune system proinflammatory response, contributing to the unique PSC phenotype.
期刊介绍:
Translating molecular bioscience and experimental research into medical insights, Clinical Science offers multi-disciplinary coverage and clinical perspectives to advance human health.
Its international Editorial Board is charged with selecting peer-reviewed original papers of the highest scientific merit covering the broad spectrum of biomedical specialities including, although not exclusively:
Cardiovascular system
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Infection and immunity
Inflammation
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