Ali Alkhaibary, Mohammed Abdulrazaq Alharbi, Sami Khairy
{"title":"Adult-onset giant mediastinal neuroblastoma.","authors":"Ali Alkhaibary, Mohammed Abdulrazaq Alharbi, Sami Khairy","doi":"10.25259/SNI_800_2024","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Neuroblastoma is a neurogenic tumor typically diagnosed in children <5 years of age. It arises from immature neural crest cells of the medulla of the adrenal gland or, less commonly, along the paravertebral sympathetic chain. We hereby report a patient with adult-onset giant mediastinal neuroblastoma.</p><p><strong>Case description: </strong>A 34-year-old female presented with mid-thoracic back pain radiating to the ribs for 1 month. The neurological examination showed decreased sensation at the left T6-T12 dermatomes. Radiological imaging revealed a giant left mediastinal paravertebral soft-tissue lesion. The patient underwent a posterolateral thoracotomy and resection of the lesion. The histopathological sections were compatible with mediastinal neuroblastoma (Differentiating subtype).</p><p><strong>Conclusion: </strong>Adult-onset neuroblastoma has been rarely reported in the literature. The present article discusses the clinicoradiological features of an adult patient with giant mediastinal neuroblastoma.</p>","PeriodicalId":94217,"journal":{"name":"Surgical neurology international","volume":"16 ","pages":"170"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134807/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgical neurology international","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25259/SNI_800_2024","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Background: Neuroblastoma is a neurogenic tumor typically diagnosed in children <5 years of age. It arises from immature neural crest cells of the medulla of the adrenal gland or, less commonly, along the paravertebral sympathetic chain. We hereby report a patient with adult-onset giant mediastinal neuroblastoma.
Case description: A 34-year-old female presented with mid-thoracic back pain radiating to the ribs for 1 month. The neurological examination showed decreased sensation at the left T6-T12 dermatomes. Radiological imaging revealed a giant left mediastinal paravertebral soft-tissue lesion. The patient underwent a posterolateral thoracotomy and resection of the lesion. The histopathological sections were compatible with mediastinal neuroblastoma (Differentiating subtype).
Conclusion: Adult-onset neuroblastoma has been rarely reported in the literature. The present article discusses the clinicoradiological features of an adult patient with giant mediastinal neuroblastoma.
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