{"title":"Current status and challenges of minimally invasive ultrasound thermal ablation technology.","authors":"Shengrong Lin, Kang Chen, Jianming Wen","doi":"10.1088/1361-6560/ade111","DOIUrl":null,"url":null,"abstract":"<p><p>Image-guided minimally invasive ultrasound thermal ablation has been widely studied for disease treatment due to its unique advantages, such as large treatment volumes and conformal delivery of ablation energy. This review presents the state-of-the-art of this technology and highlights the challenges. Ultrasound applicator designs, common image guidance methods, and treatment sites are first summarized. The recent decade has shown that despite the continuous development of this technology, only limited clinical translations have succeeded. To push this technology forward, challenges regarding the advancement of applicators, precise and real-time imaging guidance methods, and the validation of the clinical effectiveness of potential treatment sites are described. Finally, future directions are discussed. It is envisioned that future development of artificial intelligence-powered applicators with conformal ablation ability and multi-modal image guidance will enable surgeons to perform precise, visible, customizable treatment.</p>","PeriodicalId":20185,"journal":{"name":"Physics in medicine and biology","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics in medicine and biology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6560/ade111","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Image-guided minimally invasive ultrasound thermal ablation has been widely studied for disease treatment due to its unique advantages, such as large treatment volumes and conformal delivery of ablation energy. This review presents the state-of-the-art of this technology and highlights the challenges. Ultrasound applicator designs, common image guidance methods, and treatment sites are first summarized. The recent decade has shown that despite the continuous development of this technology, only limited clinical translations have succeeded. To push this technology forward, challenges regarding the advancement of applicators, precise and real-time imaging guidance methods, and the validation of the clinical effectiveness of potential treatment sites are described. Finally, future directions are discussed. It is envisioned that future development of artificial intelligence-powered applicators with conformal ablation ability and multi-modal image guidance will enable surgeons to perform precise, visible, customizable treatment.
期刊介绍：
The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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