The impact of sarcopenia on the progression of chronic non-bacterial osteomyelitis.

IF 4.1 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2025-06-04 DOI:10.1186/s13244-025-02001-w

Daniel Vogele, Janine Akbulut, Franziska Müller-Reichart, Aleš Janda, Henner Morbach, Hermann J Girschick, Matthias C Schaal, Meinrad Beer, Clemens Benoit

{"title":"The impact of sarcopenia on the progression of chronic non-bacterial osteomyelitis.","authors":"Daniel Vogele, Janine Akbulut, Franziska Müller-Reichart, Aleš Janda, Henner Morbach, Hermann J Girschick, Matthias C Schaal, Meinrad Beer, Clemens Benoit","doi":"10.1186/s13244-025-02001-w","DOIUrl":null,"url":null,"abstract":"Objectives: Chronic non-bacterial osteomyelitis (CNO) is the most common autoinflammatory bone disease in children and adolescents. This study investigated the progression of CNO lesions during therapy and the potential impact of sarcopenia on disease progression, utilizing routine MRI.Methods: A retrospective analysis of MRI examinations was conducted on 29 children and adolescents with CNO. CNO lesions were segmented. Sarcopenia was assessed using the total psoas muscle index (PMI) at lumbar vertebral levels L3/4 and L4/5. Measurements were taken at four time points during the disease course (T1: baseline, T2-T4: follow-up). Based on the PMI, patients were classified as sarcopenic or non-sarcopenic, and the progression of CNO lesions and the impact of sarcopenia were analyzed.Results: A total of 29 patients, aged 1-16 years, were included in the study, with 13 males and 16 females. Patients with sarcopenia had a significantly larger mean lesion area (868.95 mm2, SD = 684.49) compared to those without sarcopenia (636.11 mm2, SD = 832.41); p = 0.042, d = 0.4). The comparison between the two patient groups revealed a consistently lower percentage reduction in lesion size for the sarcopenic patients at all time points. Notably, the difference between T1 and T3 was statistically significant (p = 0.045, d = 0.82).Conclusion: The present study indicates that sarcopenia may serve as a negative prognostic factor in the treatment of CNO. Incorporating sarcopenia assessment as an additional parameter in routine whole-body MRI examinations could enhance the evaluation process.Critical relevance statement: Sarcopenia can be assessed using routine whole-body MRI in patients with CNO and may serve as a negative prognostic factor, potentially enhancing the evaluation process.Key points: Whole-body MRI is crucial for diagnosing and monitoring CNO. Routine whole-body MRI in CNO patients can also be used to assess sarcopenia as an additional parameter. Sarcopenia may act as a negative prognostic factor in CNO treatment, potentially improving the evaluation process.","PeriodicalId":13639,"journal":{"name":"Insights into Imaging","volume":"16 1","pages":"117"},"PeriodicalIF":4.1000,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137865/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Insights into Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13244-025-02001-w","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: Chronic non-bacterial osteomyelitis (CNO) is the most common autoinflammatory bone disease in children and adolescents. This study investigated the progression of CNO lesions during therapy and the potential impact of sarcopenia on disease progression, utilizing routine MRI.

Methods: A retrospective analysis of MRI examinations was conducted on 29 children and adolescents with CNO. CNO lesions were segmented. Sarcopenia was assessed using the total psoas muscle index (PMI) at lumbar vertebral levels L3/4 and L4/5. Measurements were taken at four time points during the disease course (T1: baseline, T2-T4: follow-up). Based on the PMI, patients were classified as sarcopenic or non-sarcopenic, and the progression of CNO lesions and the impact of sarcopenia were analyzed.

Results: A total of 29 patients, aged 1-16 years, were included in the study, with 13 males and 16 females. Patients with sarcopenia had a significantly larger mean lesion area (868.95 mm², SD = 684.49) compared to those without sarcopenia (636.11 mm², SD = 832.41); p = 0.042, d = 0.4). The comparison between the two patient groups revealed a consistently lower percentage reduction in lesion size for the sarcopenic patients at all time points. Notably, the difference between T1 and T3 was statistically significant (p = 0.045, d = 0.82).

Conclusion: The present study indicates that sarcopenia may serve as a negative prognostic factor in the treatment of CNO. Incorporating sarcopenia assessment as an additional parameter in routine whole-body MRI examinations could enhance the evaluation process.

Critical relevance statement: Sarcopenia can be assessed using routine whole-body MRI in patients with CNO and may serve as a negative prognostic factor, potentially enhancing the evaluation process.

Key points: Whole-body MRI is crucial for diagnosing and monitoring CNO. Routine whole-body MRI in CNO patients can also be used to assess sarcopenia as an additional parameter. Sarcopenia may act as a negative prognostic factor in CNO treatment, potentially improving the evaluation process.

查看原文本刊更多论文

肌肉减少症对慢性非细菌性骨髓炎进展的影响。

目的：慢性非细菌性骨髓炎（CNO）是儿童和青少年中最常见的自身炎症性骨病。本研究利用常规MRI研究了治疗期间CNO病变的进展以及肌肉减少症对疾病进展的潜在影响。方法：对29例CNO患儿的MRI检查结果进行回顾性分析。CNO病变被分割。采用腰大肌总指数（PMI）在腰椎L3/4和L4/5水平评估肌肉减少症。在病程中的四个时间点进行测量（T1：基线，T2-T4：随访）。根据PMI将患者分为肌少症和非肌少症，分析CNO病变的进展和肌少症的影响。结果：共纳入29例患者，年龄1 ~ 16岁，其中男性13例，女性16例。骨骼肌减少症患者的平均病变面积（868.95 mm2, SD = 684.49）明显大于非骨骼肌减少症患者（636.11 mm2, SD = 832.41）；P = 0.042, d = 0.4)。两组患者之间的比较显示，在所有时间点，肌肉减少症患者的病变大小减少百分比始终较低。值得注意的是，T1与T3之间的差异有统计学意义（p = 0.045, d = 0.82）。结论：骨骼肌减少症可能是影响CNO治疗预后的一个不利因素。将肌少症评估作为常规全身MRI检查的附加参数可以增强评估过程。关键相关性声明：骨骼肌减少症可以通过常规全身MRI对CNO患者进行评估，并可能作为负面预后因素，潜在地增强评估过程。重点：全身MRI对CNO的诊断和监测至关重要。CNO患者的常规全身MRI也可作为附加参数用于评估肌肉减少症。骨骼肌减少症可能是CNO治疗中的一个负面预后因素，可能会改善评估过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.