Novel insights in the regulation of intercalated cell differentiation.

IF 2.2 3区医学 Q3 PERIPHERAL VASCULAR DISEASE

Current Opinion in Nephrology and Hypertension Pub Date : 2025-06-05 DOI:10.1097/MNH.0000000000001095

Yu Feng, Yanmiao Qi, Xiangjian Zheng

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引用次数: 0

Abstract

Purpose of review: Kidney intercalated cells play critical roles in regulating body acid-base balance. We recently discovered Foxp1 and two downstream transcriptional factors Dmrt2 and Hmx2 are essential for intercalated cell differentiation. This review incorporates these findings with previous reports to add insights to the molecular regulation of intercalated cell differentiation.

Recent findings: We reviewed the current understanding of intercalated cell differentiation and plasticity, and the contribution of single-cell sequencing to point to the existence of transitional cells during principal cell and intercalated cell differentiation or trans-differentiation. For molecular regulation of cell differentiation, we discuss how Notch and Foxi1 regulate principal cell/intercalated cell switch and intercalated cell differentiation, and the new finding of Foxp1 and downstream transcriptional factors in intercalated cell subtype specification.

Summary: The differentiation and balance of principal cell and intercalated cell subtypes are the foundation for maintaining acid-base balance. A clear understanding of the cellular and molecular controls of these processes provides the basis for designing intervention approaches for metabolism acidosis or alkalosis and other related diseases.

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插层细胞分化调控的新见解。

综述目的：肾插层细胞在调节机体酸碱平衡中起重要作用。我们最近发现Foxp1和两个下游转录因子Dmrt2和Hmx2对插层细胞分化至关重要。本综述将这些发现与先前的报道相结合，以增加对插层细胞分化的分子调控的见解。最近的发现：我们回顾了目前对插层细胞分化和可塑性的理解，以及单细胞测序的贡献，指出在主细胞和插层细胞分化或反分化过程中存在移行细胞。在细胞分化的分子调控方面，我们讨论了Notch和Foxp1如何调控主细胞/插层细胞切换和插层细胞分化，以及Foxp1和下游转录因子在插层细胞亚型规范中的新发现。主细胞和插层细胞亚型的分化和平衡是维持酸碱平衡的基础。清楚地了解这些过程的细胞和分子控制为设计代谢酸中毒或碱中毒及其他相关疾病的干预方法提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Nephrology and Hypertension 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

6.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： A reader-friendly resource, Current Opinion in Nephrology and Hypertension provides an up-to-date account of the most important advances in the field of nephrology and hypertension. Each issue contains either two or three sections delivering a diverse and comprehensive coverage of all the key issues, including pathophysiology of hypertension, circulation and hemodynamics, and clinical nephrology. Current Opinion in Nephrology and Hypertension is an indispensable journal for the busy clinician, researcher or student.