Association Between the Amount of Carotid Perivascular Adipose Tissue and Prior Ischemic Stroke: An MR Imaging Study.

IF 7.4 1区医学 Q1 HEMATOLOGY

Arteriosclerosis, Thrombosis, and Vascular Biology Pub Date : 2025-08-01 Epub Date: 2025-06-05 DOI:10.1161/ATVBAHA.125.322687

Shuwan Yu, Ran Huo, Xueyi Chen, Xiaowei Song, Huiyu Qiao, Zihan Ning, Huimin Xu, Dandan Yang, Decheng Meng, Ning Xu, Zixuan Lin, Ying Liu, Xihai Zhao

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Abstract

Background: This study aimed to explore the association between the amount of carotid artery perivascular adipose tissue (PVAT) quantified by magnetic resonance imaging and prior cerebral infarction.

Methods: A total of 139 patients (mean age, 64.4±8.2 years; 112 men) with moderate-to-severe atherosclerotic stenosis referred to carotid endarterectomy were included and underwent multicontrast magnetic resonance vessel wall and brain imaging. The amount of carotid artery PVAT with vulnerable plaque components on magnetic resonance images of each patient was quantitatively analyzed, and the measurements included the average PVAT area, PVAT area index, and PVAT volume index. The amount measurements of PVAT at slices with vulnerable plaque between patients with and without prior cerebral infarction were compared. Logistic regression analyses were conducted to determine the association between the amount measurements of PVAT and prior cerebral infarction.

Results: Patients with prior cerebral infarction showed significantly higher PVAT area, PVAT area index, and PVAT volume index compared with those without (all P<0.01). The carotid PVAT area (odds ratio [OR], 1.015 [95% CI, 1.003-1.028]; P=0.018), PVAT area index (OR, 2.051 [95% CI, 1.084-3.880]; P=0.027), and PVAT volume index (OR, 2.864 [95% CI, 1.343-6.108]; P=0.006) on the index side were significantly associated with prior cerebral infarction in univariate logistic regression. After adjusting for clinical confounding factors and plaque features, the associations between carotid PVAT area (OR, 1.028 [95% CI, 1.008-1.048]; P=0.006), PVAT area index (OR, 3.587 [95% CI, 1.451-8.870]; P=0.006), and PVAT volume index (OR, 6.053 [95% CI, 2.048-17.889]; P=0.001) and prior cerebral infarction remained statistically significant.

Conclusions: The amount of PVAT in carotid artery with vulnerable plaques is independently associated with prior cerebral infarction and may, therefore, be related to the occurrence of ischemic stroke.

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磁共振成像测量颈动脉血管周围脂肪组织的数量：缺血性卒中风险的潜在指标。

背景：本研究旨在探讨磁共振成像量化颈动脉血管周围脂肪组织（PVAT）的数量与既往脑梗死的关系。方法：139例患者(平均年龄64.4±8.2岁；纳入112例（男性）中至重度动脉粥样硬化性狭窄，行颈动脉内膜切除术，并行多层对比磁共振血管壁和脑成像。定量分析每位患者磁共振图像上颈动脉易损斑块成分PVAT的数量，测量包括平均PVAT面积、PVAT面积指数、PVAT体积指数。比较有无脑梗死患者易损斑块切片的PVAT含量。进行Logistic回归分析以确定PVAT测量值与既往脑梗死之间的关联。结果：既往脑梗死患者的PVAT面积、PVAT面积指数、PVAT体积指数（均PP=0.018）、PVAT面积指数（OR, 2.051 [95% CI, 1.084 ~ 3.880]）显著高于无脑梗死患者；P=0.027)， PVAT体积指数(OR, 2.864 [95% CI, 1.343-6.108]；P=0.006)与既往脑梗死显著相关。在调整临床混杂因素和斑块特征后，颈动脉PVAT面积(OR, 1.028 [95% CI, 1.008-1.048]；P=0.006)， PVAT面积指数(OR, 3.587 [95% CI, 1.451-8.870]；P=0.006)， PVAT体积指数(OR, 6.053 [95% CI, 2.048-17.889]；P=0.001)，既往脑梗死仍有统计学意义。结论：易损斑块颈动脉PVAT含量与既往脑梗死独立相关，可能与缺血性脑卒中的发生有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arteriosclerosis, Thrombosis, and Vascular Biology 医学-外周血管病

CiteScore

15.60

自引率

2.30%

发文量

337

审稿时长

2-4 weeks

期刊介绍： The journal "Arteriosclerosis, Thrombosis, and Vascular Biology" (ATVB) is a scientific publication that focuses on the fields of vascular biology, atherosclerosis, and thrombosis. It is a peer-reviewed journal that publishes original research articles, reviews, and other scholarly content related to these areas. The journal is published by the American Heart Association (AHA) and the American Stroke Association (ASA). The journal was published bi-monthly until January 1992, after which it transitioned to a monthly publication schedule. The journal is aimed at a professional audience, including academic cardiologists, vascular biologists, physiologists, pharmacologists and hematologists.