Unlocking molecular secrets: The role of miRNAs in Parkinson's disease dynamics

Abstract

Parkinson's disease (PD) is a devastating neurological age-related ailment that causes dysfunction in the motor system, leading to symptoms such as involuntary shaking at rest, muscle stiffness with jerky movements, difficulty with walking, sluggish movement, and issues in sustaining posture. A state of insufficient dopamine in the striatum can be linked to a significant decrease in dopaminergic neurons within the substantia nigra pars compacta. Likewise, the formation of Lewy bodies is a distinctive pathogenic feature of PD. Although contemporary therapeutic strategies for PD focus on preserving dopaminergic neurons or restoring dopamine levels in the brain, it is crucial to recognize that achieving total remission of the illness is still inaccessible. MicroRNAs (miRNAs) are a group of tiny RNAs that do not code for proteins. They play a substantial role in controlling gene expression after the process of transcription. miRNAs have a pivotal role in the underlying pathological mechanisms of various neurodegenerative diseases, including PD. The objective of this research initiative is to create a molecular network in order to identify miRNAs that have significant impacts on the evolution of PD, with the intention of utilising them for instant diagnosis as well as prompt prognosis.