Mannich base derivatives in neurological disorders: A comprehensive review with SAR approach

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2025-06-05 DOI:10.1016/j.molstruc.2025.142669

Samiksha Srivastava , Avinash C. Tripathi , Mayank Yadav

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Abstract

Mannich bases, a class of β-amino-ketone compounds formed through the condensation of an amine, an aldehyde (such as formalin), and a carbon acid, have garnered significant attention for their wide-ranging pharmacological potential. This review explores the synthesis of various types of Mannich bases, including commercially available and naturally derived compounds, highlighting their role in treating neurological disorders. Mannich bases have demonstrated diverse pharmacological activities, such as anticonvulsant, anti-alzheimer, anti-Parkinson, antidepressant, anxiolytic, sedative, hypnotic, and antinociceptive effects. The review also delves into structure–activity relationships (SARs) revealed through extensive literature findings, offering insights into their therapeutic mechanisms in central nervous system (CNS) diseases. Additionally, recent patents on Mannich bases in the context of CNS-related disorders are discussed, providing a comprehensive overview of their potential in drug development.

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神经系统疾病中的曼尼希碱衍生物：SAR方法的综合综述

曼尼希碱是一类由胺、醛（如福尔马林）和碳酸缩合而成的β-氨基酮化合物，因其广泛的药理潜力而引起了广泛的关注。这篇综述探讨了各种类型的曼尼希碱的合成，包括市售和天然衍生的化合物，强调了它们在治疗神经系统疾病中的作用。曼尼希碱已被证明具有多种药理活性，如抗惊厥、抗阿尔茨海默病、抗帕金森、抗抑郁、抗焦虑、镇静、催眠和抗伤害作用。本综述还深入探讨了通过大量文献发现揭示的结构-活性关系（SARs），为其在中枢神经系统（CNS）疾病中的治疗机制提供了见解。此外，本文还讨论了最近针对中枢神经系统相关疾病的曼尼希专利，全面概述了它们在药物开发中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.