Cycloruthenated thiophene-imines: novel anticancer agents

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry Pub Date : 2025-05-28 DOI:10.1016/j.jorganchem.2025.123726

Aleksei V. Medved’ko , Arsenii A. Vasil’ev , Mikhail A. Kiskin , Mikhail A. Syroeshkin , Viсtoriya A. Balycheva , Nikolai A. Melnichuk , Alexey A. Nazarov , Sergey Z. Vatsadze

引用次数: 0

Abstract

The search for new anticancer drugs is still a very important task for modern chemistry. Some of the most intensively studied objects are metal complexes, in particular complexes of platinum, ruthenium, iridium and osmium. To address this issue, novel organometallic ruthenium complexes with thiophene-based imines containing a Ru-C bond were synthesized and tested against cancer cell lines. The scaffold is designed to allow the generation of a broad library of cyclometallated compounds from commercially available substrates. Compounds were characterized using spectroscopic, electrochemical, and X-ray diffraction techniques. They were found to have a very good cytotoxicity among ruthenium complexes against A2780, A549 and MCF-7 cancer cells and against HEK cells.

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环脲基噻吩亚胺：新型抗癌剂

寻找新的抗癌药物仍然是现代化学的一项重要任务。一些最深入研究的对象是金属配合物，特别是铂、钌、铱和锇的配合物。为了解决这个问题，新的有机金属钌配合物与含有Ru-C键的噻吩基亚胺被合成并对癌细胞系进行了测试。该支架的设计允许从商业上可用的底物产生广泛的环金属化化合物库。利用光谱、电化学和x射线衍射技术对化合物进行了表征。在钌配合物中发现它们对A2780、A549和MCF-7癌细胞和HEK细胞具有很好的细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organometallic Chemistry 化学-无机化学与核化学

CiteScore

4.40

自引率

8.70%

发文量

221

审稿时长

36 days

期刊介绍： The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.