Kidney Donors' Perceived and Measured Stress Levels Before and After Donation, a Longitudinal Cohort Study

IF 1.9 4区医学 Q2 SURGERY

Clinical Transplantation Pub Date : 2025-06-06 DOI:10.1111/ctr.70208

Jenny Stenberg, Annette Lennerling, Helen Andersson, Maria K. Svensson

{"title":"Kidney Donors' Perceived and Measured Stress Levels Before and After Donation, a Longitudinal Cohort Study","authors":"Jenny Stenberg, Annette Lennerling, Helen Andersson, Maria K. Svensson","doi":"10.1111/ctr.70208","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Transplantation with a kidney from a living donor has superior long-term patient and graft survival compared to a kidney from a deceased donor. For a kidney donor, feelings of stress may exist at different stages of the donation process. The aim of the study was to evaluate living kidney donors’ perceived and measured stress levels before and after donation.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In this prospective observational cohort study with longitudinal follow-up, kidney donors were invited to answer three self-rating questionnaires targeting stress, vital exhaustion, and depressive symptoms the day before and two and six months after kidney donation. At the same time points, blood and saliva samples of insulin, glucose, and cortisol were collected.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Analyses were based on data from seventy-five individuals, with a mean age 46.5 (11) years, 60% women. The kidney donors scored low in self-rating stress, exhaustion and depression both pre- and two and six months post-donation, and no correlations were established between self-reported measures and metabolic stress biomarkers. Post-donation, however, a gender difference emerged, with women reporting decreased vitality scores 32.1 (9.3) and 30.7 (11.6) at two and six months versus men reporting increased scores 35.8 (6.9) and 36.9 (7.1). Six months post-donation, women also reported more symptoms of depression than men, 12.2 (12.5) versus 6.4 (8.2) (<i>p</i> = 0.058).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Kidney donors’ self-reported and measured stress levels and depressive symptoms were low and did not change from pre-donation up to six months after donation. The low levels of subjective and objective stress reported by the donors support the limited risks associated with living kidney donation. However, six months post-donation, women reported more feelings of exhaustion and depression than did men. Practitioner points: (1) The low levels of subjective and objective stress reported by kidney donors support the limited risks associated with living kidney donation. (2) Because most kidney donors are women, the gender difference in perceived stress levels presented in this study is of clinical relevance. (3) A more structured psychosocial follow-up could enable the identification of individuals in need of more psychological follow-up post-donation.</p>\n </section>\n </div>","PeriodicalId":10467,"journal":{"name":"Clinical Transplantation","volume":"39 6","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ctr.70208","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Transplantation","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ctr.70208","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Transplantation with a kidney from a living donor has superior long-term patient and graft survival compared to a kidney from a deceased donor. For a kidney donor, feelings of stress may exist at different stages of the donation process. The aim of the study was to evaluate living kidney donors’ perceived and measured stress levels before and after donation.

Methods

In this prospective observational cohort study with longitudinal follow-up, kidney donors were invited to answer three self-rating questionnaires targeting stress, vital exhaustion, and depressive symptoms the day before and two and six months after kidney donation. At the same time points, blood and saliva samples of insulin, glucose, and cortisol were collected.

Results

Analyses were based on data from seventy-five individuals, with a mean age 46.5 (11) years, 60% women. The kidney donors scored low in self-rating stress, exhaustion and depression both pre- and two and six months post-donation, and no correlations were established between self-reported measures and metabolic stress biomarkers. Post-donation, however, a gender difference emerged, with women reporting decreased vitality scores 32.1 (9.3) and 30.7 (11.6) at two and six months versus men reporting increased scores 35.8 (6.9) and 36.9 (7.1). Six months post-donation, women also reported more symptoms of depression than men, 12.2 (12.5) versus 6.4 (8.2) (p = 0.058).

Conclusions

Kidney donors’ self-reported and measured stress levels and depressive symptoms were low and did not change from pre-donation up to six months after donation. The low levels of subjective and objective stress reported by the donors support the limited risks associated with living kidney donation. However, six months post-donation, women reported more feelings of exhaustion and depression than did men. Practitioner points: (1) The low levels of subjective and objective stress reported by kidney donors support the limited risks associated with living kidney donation. (2) Because most kidney donors are women, the gender difference in perceived stress levels presented in this study is of clinical relevance. (3) A more structured psychosocial follow-up could enable the identification of individuals in need of more psychological follow-up post-donation.

查看原文本刊更多论文

肾脏捐赠者在捐献前后感知和测量的压力水平，一项纵向队列研究

与已故供者的肾脏相比，活体供者的肾脏移植具有更好的长期患者和移植存活率。对于肾脏捐赠者来说，压力感可能存在于捐赠过程的不同阶段。该研究的目的是评估活体肾脏捐赠者在捐赠前后的感知和测量压力水平。方法采用纵向随访的前瞻性观察队列研究，邀请肾脏捐赠者在捐献肾脏前一天、捐献肾脏后2个月和6个月分别回答3份针对压力、生命衰竭和抑郁症状的自评问卷。在同一时间点，收集血液和唾液中胰岛素、葡萄糖和皮质醇的样本。结果分析基于75个个体的数据，平均年龄46.5（11）岁，60%为女性。肾脏捐赠者在捐赠前、捐赠后2个月和6个月的自我评估压力、疲惫和抑郁方面得分都很低，自我报告的测量结果与代谢压力生物标志物之间没有相关性。然而，捐献后出现了性别差异，女性在2个月和6个月时的活力得分分别为32.1（9.3）和30.7(11.6)，而男性则分别为35.8（6.9）和36.9（7.1）。捐献后6个月，女性报告的抑郁症状也多于男性，分别为12.2（12.5）和6.4 (8.2)（p = 0.058）。结论肾脏供者自我报告和测量的应激水平和抑郁症状较低，且从捐献前到捐献后6个月没有变化。捐献者报告的低水平主观和客观压力支持活体肾脏捐赠相关的有限风险。然而，在捐赠后6个月，女性比男性报告了更多的疲惫和抑郁感。医生指出：(1)肾脏捐赠者报告的主观和客观压力水平较低，支持活体肾脏捐赠的风险有限。(2)由于大多数肾脏供者为女性，因此本研究中呈现的感知压力水平的性别差异具有临床相关性。(3)更结构化的社会心理随访可以识别出捐赠后需要更多心理随访的个体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Transplantation 医学-外科

CiteScore

3.70

自引率

4.80%

发文量

286

审稿时长

2 months

期刊介绍： Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored. Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include: Immunology and immunosuppression; Patient preparation; Social, ethical, and psychological issues; Complications, short- and long-term results; Artificial organs; Donation and preservation of organ and tissue; Translational studies; Advances in tissue typing; Updates on transplant pathology;. Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries. Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.