Effect of bioactive glass toothpaste on the white spots around orthodontic brackets: A systematic review and meta-analysis.

Q4 Dentistry

Journal of Dental Research, Dental Clinics, Dental Prospects Pub Date : 2025-03-31 eCollection Date: 2025-03-01 DOI:10.34172/joddd.025.41686

Arezoo Jahanbin, Reyhaneh Hanaei, Erfan Bardideh, Maryam Omidkhoda, Farnaz Zia

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引用次数: 0

Abstract

Background: White spot lesions (WSLs), early indicators of tooth decay, are common in patients with fixed orthodontic appliances and can disrupt esthetic outcomes. Various methods have been proposed to prevent and treat WSLs, with bioactive glass products being one of the latest approaches. This study aims to evaluate the effect of bioactive glass toothpastes on WSLs around orthodontic brackets.

Methods: Relevant articles were identified using databases such as PubMed, EMBASE, Cochrane's CENTRAL, Scopus, and Web of Science up to November 2023. The full texts of selected studies were retrieved, and their quality was assessed. The study included clinical and in vitro research. Four clinical studies (2015‒2023) were reviewed, with meta-analysis performed on three. A random-effects inverse variance meta-analysis was performed, and the quality of the evidence was graded using GRADE.

Results: No significant difference was found between bioactive glass and fluoride toothpaste in remineralizing WSLs (P=0.10, SMD=-0.29). Nine in vitro studies (2013‒2022) were reviewed, with a meta-analysis on three showing significant lesion depth reduction with bioactive glass compared to no treatment (P<0.00001, MD=-63.98).

Conclusion: Bioactive glass toothpaste may be effective in remineralizing WSLs, though its efficacy is not significantly different from conventional fluoride toothpaste.

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生物活性玻璃牙膏对正畸托槽周围白斑的影响：系统回顾和荟萃分析。

背景：白斑病变（WSLs）是牙齿腐烂的早期指标，在使用固定正畸器的患者中很常见，并且可以破坏美观效果。人们提出了各种预防和治疗wsl的方法，生物活性玻璃产品是最新的方法之一。本研究旨在评价生物活性玻璃牙膏对正畸托槽周围牙釉质损伤的影响。方法：使用截至2023年11月的PubMed、EMBASE、Cochrane’s CENTRAL、Scopus和Web of Science等数据库对相关文章进行检索。检索选定研究的全文，并对其质量进行评估。该研究包括临床和体外研究。回顾了4项临床研究（2015-2023），并对其中3项进行了荟萃分析。进行随机效应反方差荟萃分析，并使用GRADE对证据质量进行分级。结果：生物活性玻璃与含氟牙膏对wsl再矿化效果无显著性差异（P=0.10， SMD=-0.29）。我们回顾了2013-2022年的9项体外研究，其中3项荟萃分析显示，与未治疗相比，生物活性玻璃可显著减少病变深度(p结论：生物活性玻璃牙膏可能对wsl再矿化有效，但其疗效与常规含氟牙膏无显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Dental Research, Dental Clinics, Dental Prospects Dentistry-General Dentistry

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

25 weeks

期刊介绍： Journal of Dental Research Dental Clinics Dental Prospects (JODDD) is a Platinum* Open Access, peer-reviewed quarterly indexed journal that publishes articles of basic, clinical, and prospective nature in all areas of dentistry and oral health.