Pre-Operative Radiological Diagnosis of Appendiceal Neuroendocrine Neoplasms: Implications for Conservative Management of Acute Appendicitis

IF 1.6 4区 医学 Q3 SURGERY
Orit Twito, Shai Ken Dror, Maya Paran, Feda Fanadka, Rachel Chava Rosenblum, Adi Rov, Haim Paran
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Abstract

Background

Non-surgical treatment of appendicitis carries the risk of missed tumors, such as appendiceal neuroendocrine neoplasms (ANEN), the most common appendiceal tumor. The aim of this study is to identify radiological features of ANEN that will distinguish them from simple acute appendicitis.

Methods

Data were extracted from a database of 8327 appendectomies conducted during 2005–2018. Pre-operative computerized tomography (CT) or ultrasound (US) scans of patients with ANEN and a random sample of patients with simple appendicitis were compared. Patients with other appendiceal tumors were excluded. All images were reviewed by a blinded, experienced radiologist.

Results

Thirty-five ANEN (20 CT, 15 US) were compared to 50 cases with simple appendicitis (30 CT, 20 US). Age was similar between study groups (33.8 ± 19.2 vs. 35.2 ± 17.9, respectively, p = 0.378); female gender was more prevalent in the ANEN group (65.7% vs. 38.3%, p = 0.017). ANEN size per pathology report was 17.0 ± 13.4 mm, and mesoappendix invasion was evident in 37.1%. Appendiceal diameter, regional lymph node number, and size were similar. Evidence of solid tissue in the appendiceal lumen per CT was more prevalent in the ANEN group compared to controls (7/20 [35%] vs. 2/30 [6.7%], p = 0.0008).

Conclusions

Although the majority of ANEN cannot be identified in pre-appendectomy imaging, 35% of cases demonstrate the presence of solid tissue in the appendiceal lumen. This finding may distinguish these patients from those with simple appendicitis and should lead to early surgical intervention, or close and more cautious surveillance if a conservative approach is chosen.

Abstract Image

阑尾神经内分泌肿瘤的术前放射学诊断:对急性阑尾炎保守治疗的意义。
背景:阑尾炎的非手术治疗有遗漏肿瘤的风险,如阑尾神经内分泌肿瘤(ANEN),是最常见的阑尾肿瘤。本研究的目的是确定ANEN的影像学特征,将其与单纯性急性阑尾炎区分开来。方法:数据提取自2005-2018年进行的8327例阑尾切除术数据库。比较ANEN患者术前计算机断层扫描(CT)或超声扫描(US)与随机抽样的单纯性阑尾炎患者。排除其他阑尾肿瘤患者。所有图像都由一位有经验的盲眼放射科医生检查。结果:35例ANEN (20 CT, 15 US)与50例单纯性阑尾炎(30 CT, 20 US)相比较。研究组间年龄相似(分别为33.8±19.2∶35.2±17.9,p = 0.378);女性在ANEN组中更为普遍(65.7%比38.3%,p = 0.017)。病理报告ANEN大小为17.0±13.4 mm, 37.1%阑尾系膜明显侵犯。阑尾直径、区域淋巴结数目和大小相似。与对照组相比,ANEN组阑尾腔内实性组织的CT显示更为普遍(7/20[35%]比2/30 [6.7%],p = 0.0008)。结论:虽然大多数ANEN不能在阑尾切除术前的影像学中被发现,但35%的病例显示阑尾管腔内存在实体组织。这一发现可以将这些患者与单纯阑尾炎患者区分开来,并应进行早期手术干预,或在选择保守方法时进行密切和更谨慎的监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ANZ Journal of Surgery
ANZ Journal of Surgery 医学-外科
CiteScore
2.50
自引率
11.80%
发文量
720
审稿时长
2 months
期刊介绍: ANZ Journal of Surgery is published by Wiley on behalf of the Royal Australasian College of Surgeons to provide a medium for the publication of peer-reviewed original contributions related to clinical practice and/or research in all fields of surgery and related disciplines. It also provides a programme of continuing education for surgeons. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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