Neurotoxic Effects of Airborne Particulate Matter: Mechanisms and Health Implications

IF 3.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biochemical and Molecular Toxicology Pub Date : 2025-06-04 DOI:10.1002/jbt.70322

Prakash Thangavel, Duckshin Park, Young-Chul Lee

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引用次数: 0

Abstract

Exposure to particulate matter (PM) impacts various aspects of health. PM exposure has been increasingly associated with adverse neurological effects, including both neurodevelopmental disorders and neurodegenerative diseases. This review examines the pathways through which PM affects the central nervous system (CNS), including inhalation, systemic circulation, and direct olfactory translocation, leading to neuroinflammation, oxidative stress, and disruption of the blood-brain barrier (BBB). Epidemiological and experimental studies suggest a strong correlation between PM exposure and cognitive impairments, Alzheimer's disease (AD), Multiple sclerosis, and Parkinson's disease (PD). Investigating the PM-neurodegenerative disease relationship is a pressing public health priority, offering opportunities to protect vulnerable populations from the effects of neurodegenerative diseases. The potential of PM for long-term accumulation and neurotoxicity is further demonstrated by its toxicokinetics, which include its absorption, distribution, metabolism, and excretion. Understanding these pathways is essential for developing solutions to reduce PM-induced neurological hazards.

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空气颗粒物的神经毒性作用：机制和健康影响

接触颗粒物（PM）会影响健康的各个方面。PM暴露越来越多地与不良神经效应相关，包括神经发育障碍和神经退行性疾病。本文综述了PM影响中枢神经系统（CNS）的途径，包括吸入、体循环和直接嗅觉易位，导致神经炎症、氧化应激和血脑屏障（BBB）的破坏。流行病学和实验研究表明，PM暴露与认知障碍、阿尔茨海默病（AD）、多发性硬化症和帕金森病（PD）之间存在很强的相关性。研究pm与神经退行性疾病的关系是一项紧迫的公共卫生优先事项，为保护弱势群体免受神经退行性疾病的影响提供了机会。PM的长期积累和神经毒性的潜力进一步证明了其毒性动力学，包括其吸收、分布、代谢和排泄。了解这些途径对于制定减少pm引起的神经系统危害的解决方案至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biochemical and Molecular Toxicology 生物-毒理学

CiteScore

5.80

自引率

2.80%

发文量

277

审稿时长

6-12 weeks

期刊介绍： The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents. The scope includes effects on the organism at all stages of development, on organ systems, tissues, and cells as well as on enzymes, receptors, hormones, and genes. The biochemical and molecular aspects of uptake, transport, storage, excretion, lactivation and detoxication of drugs, agricultural, industrial and environmental chemicals, natural products and food additives are all subjects suitable for publication. Of particular interest are aspects of molecular biology related to biochemical toxicology. These include studies of the expression of genes related to detoxication and activation enzymes, toxicants with modes of action involving effects on nucleic acids, gene expression and protein synthesis, and the toxicity of products derived from biotechnology.