Calculating the minimally important difference for the FACT-E from esophageal cancer surgery to recovery using distribution-based methods.

IF 2.6 3区 医学
Trafford Crump, Mehrnoush Dehghani, Jason M Sutherland, Carmen Mueller, Lorenzo Edwin Ferri
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Abstract

A challenge with patient-reported outcomes is interpreting changes in scores. The minimally important difference (MID) represents the smallest meaningful change in a score. This study's objective is to calculate the MID for the Functional Assessment of Cancer Therapy-Esophageal (FACT-E) and examine whether the MID changes over time from treatment through recovery. This retrospective longitudinal study analyzed data from the McGill University Esophageal and Gastric Data- and Bio-Bank. Participants were adults who underwent esophageal cancer surgery and completed the FACT-E pre-surgery and at least once post-surgery. MIDs were calculated using two distribution-based approaches: standard deviation and standard error of measurement. MIDs were calculated for the five FACT-E domains and total score at multiple time points. The study included 676 participants. MIDs varied by domain and calculation method. The MIDs ranged from 1 to 3 points for most domains, 2 to 5 points for the esophagus cancer subscale, and 4 to 9 points for the FACT-E total score. The MIDs changed over time, with the greatest fluctuations found in the esophagus cancer subscale. This study provides the first estimates of MIDs for the FACT-E, offering clinicians and researchers guidance for interpreting meaningful changes in scores. The range of MIDs can help identify potentially important changes in patient-reported symptoms and quality of life over time. Further studies using additional methods to calculate MIDs are warranted to refine these estimates.

使用基于分布的方法计算食管癌手术到恢复的FACT-E的最小重要差异。
患者报告结果的一个挑战是如何解释分数的变化。最低重要差异(MID)代表分数中最小的有意义的变化。本研究的目的是计算食管癌治疗功能评估(FACT-E)的MID,并检查MID是否随治疗至康复期间的时间变化。这项回顾性纵向研究分析了来自麦吉尔大学食管和胃数据和生物银行的数据。参与者是接受食管癌手术并完成术前和术后至少一次FACT-E的成年人。使用两种基于分布的方法计算mid:标准偏差和测量标准误差。计算五个FACT-E域的mid和多个时间点的总分。该研究包括676名参与者。MIDs随领域和计算方法的不同而不同。大多数领域的mid为1到3分,食道癌子量表为2到5分,FACT-E总分为4到9分。MIDs随时间变化,在食道癌亚量表中波动最大。本研究为FACT-E提供了MIDs的首次估计,为临床医生和研究人员提供了解释得分有意义变化的指导。MIDs的范围可以帮助识别患者报告的症状和生活质量随时间的潜在重要变化。有必要使用其他方法进行进一步的研究来计算mid,以完善这些估计。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diseases of the Esophagus
Diseases of the Esophagus Medicine-Gastroenterology
自引率
7.70%
发文量
568
期刊介绍: Diseases of the Esophagus covers all aspects of the esophagus - etiology, investigation and diagnosis, and both medical and surgical treatment.
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