Quantification electroencephalography response to procedural pain during heel puncture in preterm infants.

IF 2.7 4区医学 Q3 BIOPHYSICS

Physiological measurement Pub Date : 2025-06-27 DOI:10.1088/1361-6579/addfa9

Nusreena Hohsoh, Osuke Iwata, Tomoko Suzuki, Chinami Hanai, Ming Huang, Kiyoko Yokoyama

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引用次数: 0

Abstract

Objective. Pain assessment in preterm infants is often based on subjective observations, which may lack objectivity and are labor-intensive. Non-invasive EEG can serve as an objective assessment tool. However, no specific EEG feature within a particular frequency band and brain region has been reported for pain detection in the objective pain assessment of preterm infants. This study quantified electroencephalography (EEG) responses to procedural pain during a puncture in preterm infants, specifically analyzing three EEG parameters.Approach. Fifty-seven EEG datasets from forty-two preterm infants were analyzed across eight EEG channels. The differences between the upper and lower margins (UM-LM) of amplitude-integrated EEG (aEEG), as well as the five frequency bands (low delta, high delta, theta, alpha, and beta) of frequency power and time-frequency power, were used to characterize the response of the brain to pain during specific periods: before, during, and after the puncture.Main results. The Fp1 and Fp2 exhibited the most significant differences in the UM-LM aEEG differences between before vs during (Fp1:p= 0.0060, Fp2:p= 0.0031), before vs after (p< 0.0001), and during vs after (Fp1:p= 0.0427, Fp2:p= 0.025) the puncture. The C3 and C4 responded significantly to pain during the puncture in the frequency and time-frequency power, notably the time-frequency power in the low delta, which showed the most significant differences between the periods before vs during (p< 0.0001), before vs after (p< 0.0001), and during vs after (p= 0.0002) the puncture.Significance. The central brain region responds significantly to procedural pain in preterm infants, which is prominently detected in the low delta of time-frequency power. These findings support the use of EEG application as an objective and non-invasive method to identify and detect pain in nonverbal populations, focusing on specific critical channels and frequency bands.

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量化脑电图对早产儿足跟穿刺过程中程序性疼痛的反应。

目的：早产儿的疼痛评估通常是基于主观观察，可能缺乏客观性，并且是劳动密集型的。无创脑电图可以作为客观的评估工具。然而，在早产儿的客观疼痛评估中，没有特定的脑电图特征在特定的频带和脑区域内用于疼痛检测的报道。本研究量化了早产儿穿刺过程中程序性疼痛的脑电图（EEG）反应，具体分析了三个EEG参数。方法：对42例早产儿的57组脑电图数据进行8个脑电图通道的分析。利用振幅积分脑电图（aEEG）上下边界（UM-LM）的差异，以及频率功率和时频功率的5个频段（低δ、高δ、θ、α和β）来表征针刺前、针刺中和针刺后特定时期大脑对疼痛的反应。主要结果：Fp1和Fp2在穿刺前与穿刺中（Fp1: p = 0.0060, Fp2: p = 0.0031）、穿刺前与穿刺后（p < 0.0001）、穿刺中与穿刺后（Fp1: p = 0.0427, Fp2: p = 0.025） UM-LM aEEG差异最为显著。在穿刺过程中，C3和C4在频率和时频功率上对疼痛有明显的反应，尤其是在低δ时频功率上，在穿刺前与穿刺中（p < 0.0001）、穿刺前与穿刺后（p < 0.0001）、穿刺中与穿刺后（p < 0.0002）之间的差异最为显著。意义：中脑区对早产儿的程序性疼痛有明显的反应，这种反应在时频功率的低δ中被显著检测到。这些发现支持将脑电图应用作为一种客观、无创的方法来识别和检测非语言人群的疼痛，重点关注特定的关键通道和频段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiological measurement 生物-工程：生物医学

CiteScore

5.50

自引率

9.40%

发文量

124

审稿时长

3 months

期刊介绍： Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation. Papers are published on topics including: applied physiology in illness and health electrical bioimpedance, optical and acoustic measurement techniques advanced methods of time series and other data analysis biomedical and clinical engineering in-patient and ambulatory monitoring point-of-care technologies novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems. measurements in molecular, cellular and organ physiology and electrophysiology physiological modeling and simulation novel biomedical sensors, instruments, devices and systems measurement standards and guidelines.