Outcomes in Acute Ocular Surface Chemical Injury-Role of pH Measurement on Presentation: A Retrospective Cohort Study.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2025-06-03 DOI:10.1007/s40123-025-01155-6

Emma Spowart, Sayali Pradhan, Charlotte Bruce, Borja Salvador-Culla, Gustavo Figueiredo, Francisco C Figueiredo

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引用次数: 0

Abstract

Introduction: Chemical eye injury is an ophthalmic emergency which can lead to loss of vision. We aimed to determine the prognostic value of tear film pH on presentation in acute chemical eye injuries.

Methods: Demographics, pH values, causative chemical, injury circumstances, injury severity, and clinical and visual outcomes were assessed from previously collated data from patients presenting to the emergency eye department (EED) in a UK tertiary hospital. All patients who had pH measured before irrigation in the EED were included. Associations with injury severity and clinical and visual outcomes were analysed.

Results: Pre-irrigation pH was recorded in 135 eyes (113 patients, 66.4% male, mean age 35.5 years [range 2-78; standard deviation (SD) 15.4]; 15 acid, 108 alkali, 12 unknown). The pH within 24 h of injury (n = 108 eyes) correlated significantly with injury severity (r_s = 0.20, p = 0.02). In patients with abnormal pH on presentation (n = 26 eyes), pH correlated strongly with injury severity (r_s = 0.72, p < 0.01). There was no significant correlation with visual outcome at follow-up (n = 70 eyes, 60 patients, follow-up 1-3929 days, mean 579.4 days, SD 1206.0 days; r_s = 0.12, p = 0.11). Presenting pH below 6.5 or above 7.5 was a significant predictive factor for the presence of limbal stem cell deficiency (LSCD) (univariate binary logistic regression analysis, p = 0.026, Nagelkerke R-squared = 0.090).

Conclusion: Deranged pH correlated with burn severity in patients presenting within 24 h of injury and was a significant predictive factor for LSCD.

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急性眼表化学损伤的预后- pH测量在表现中的作用：一项回顾性队列研究。

导读：化学性眼损伤是一种可导致视力丧失的眼科急症。我们的目的是确定泪膜pH值对急性化学性眼损伤的预后价值。方法：统计数据、pH值、致病化学物质、损伤情况、损伤严重程度、临床和视力结果，从英国一家三级医院急诊科（EED）就诊的患者先前整理的数据进行评估。所有在EED冲洗前测量pH值的患者都包括在内。分析了与损伤严重程度、临床和视觉结果的关系。结果：135只眼(113例，男性66.4%，平均年龄35.5岁，范围2 ~ 78岁；标准差（SD） 15.4]；15种酸，108种碱，12种未知)。损伤24 h内pH值（n = 108眼）与损伤严重程度显著相关（rs = 0.20, p = 0.02）。在出现pH值异常的患者中（n = 26只眼），pH值与损伤严重程度密切相关（rs = 0.72, p = 0.12, p = 0.11）。pH值低于6.5或高于7.5是角膜缘干细胞缺乏症（LSCD）存在的重要预测因素（单变量二元logistic回归分析，p = 0.026, Nagelkerke r²= 0.090）。结论：损伤后24小时内出现的患者，pH紊乱与烧伤严重程度相关，是LSCD的重要预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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