Assessing MScanFit MUNE in Amyotrophic Lateral Sclerosis: Influence of Nerve Conduction Distance and Temporal Dispersion.

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Muscle & Nerve Pub Date : 2025-09-01 Epub Date: 2025-06-02 DOI:10.1002/mus.28446

Halil Can Alaydin, Ozlem Kurtkaya Kocak, Ilker Arslan, Hasan Kılınc, H Evren Boran, Hatice Tankisi, Bulent Cengiz

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引用次数: 0

Abstract

Introduction/aims: MScanFit is a promising method for motor unit number estimation (MUNE) based on compound muscle action potential (CMAP) scanning. Considering that CMAP morphology may be altered by temporal dispersion associated with nerve conduction distance, it is important to evaluate the potential impact of these changes on MScanFit measurements. Therefore, we aimed to investigate the effect of nerve conduction distance on MScanFit MUNE in patients with amyotrophic lateral sclerosis (ALS).

Methods: MScanFit MUNE was recorded from the abductor digiti minimi (ADM) muscle by stimulating the ulnar nerve at the wrist and elbow in twenty-three ALS patients. Consistency of MScanFit MUNE and size parameters, CMAP amplitude, and CMAP duration were evaluated using intraclass correlation coefficients (ICC).

Results: Significant differences were noted in CMAP amplitudes (6.35 ± 2.5 mV vs. 5.7 ± 2.4 mV; p = 0.003) and CMAP durations (5.8 ± 0.7 ms vs. 6.2 ± 0.8 ms; p < 0.001), reflecting temporal dispersion effects. MUNE values showed high consistency between wrist and elbow stimulations (61 ± 32.4 vs. 61.1 ± 30.7; p = 0.99), with an ICC of 0.86. Similar repeatability was also observed for MScanFit size parameters.

Discussion: The reliability of MScanFit MUNE in determining motor unit values in ALS patients remains consistent regardless of the stimulation distance. Our findings highlight the effectiveness of MScanFit MUNE in evaluating motor unit loss of ALS patients and demonstrate its resilience to temporal dispersion effects. Proximal stimulation serves as a viable alternative, enhancing the utility of MScanFit in clinical settings.

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肌萎缩性侧索硬化症的MScanFit MUNE评估：神经传导距离和颞弥散的影响。

MScanFit是一种很有前途的基于复合肌肉动作电位（CMAP）扫描的运动单元数估计（MUNE）方法。考虑到与神经传导距离相关的颞弥散可能改变CMAP形态，评估这些变化对MScanFit测量的潜在影响是很重要的。因此，我们旨在研究神经传导距离对肌萎缩侧索硬化症（ALS）患者MScanFit MUNE的影响。方法：对23例ALS患者通过刺激腕部和肘部尺神经，从指外展肌（ADM）记录MScanFit MUNE。使用类内相关系数（ICC）评估MScanFit MUNE与尺寸参数、CMAP振幅和CMAP持续时间的一致性。结果：CMAP振幅(6.35±2.5 mV vs. 5.7±2.4 mV；p = 0.003),提出持续时间(5.8±0.7 vs 6.2±0.8女士女士;p讨论：无论刺激距离如何，MScanFit MUNE在确定ALS患者运动单位值方面的可靠性是一致的。我们的研究结果强调了MScanFit MUNE在评估ALS患者运动单元丧失方面的有效性，并证明了其对时间弥散效应的弹性。近端刺激作为一种可行的替代方案，增强了MScanFit在临床环境中的效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Muscle & Nerve 医学-临床神经学

CiteScore

6.40

自引率

5.90%

发文量

287

审稿时长

3-6 weeks

期刊介绍： Muscle & Nerve is an international and interdisciplinary publication of original contributions, in both health and disease, concerning studies of the muscle, the neuromuscular junction, the peripheral motor, sensory and autonomic neurons, and the central nervous system where the behavior of the peripheral nervous system is clarified. Appearing monthly, Muscle & Nerve publishes clinical studies and clinically relevant research reports in the fields of anatomy, biochemistry, cell biology, electrophysiology and electrodiagnosis, epidemiology, genetics, immunology, pathology, pharmacology, physiology, toxicology, and virology. The Journal welcomes articles and reports on basic clinical electrophysiology and electrodiagnosis. We expedite some papers dealing with timely topics to keep up with the fast-moving pace of science, based on the referees'' recommendation.