Rufaida Wasim, Sumaiya Azmi, Mohammad Owais, Aamir Anwar
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引用次数: 0
Abstract
A complex and multifaceted metabolic disease, type 2 diabetes mellitus (T2DM) is becoming a significant public health concern. Due to their many biological characteristics, bioactive compounds from herbal medicine have been shown in multiple studies to have positive benefits on the prevention and control of type 2 diabetes. The scientific community is becoming more interested in curcumin, one of these therapeutic herbs. The plant Curcuma longa, often known as turmeric, has a bioactive compound called curcumin in its rhizome. Antioxidant, cardio-protective, anti-inflammatory, anti-microbial, nephro-protective, anti-neoplastic, hepato-protective, immunomodulatory, hypoglycemic, and anti-rheumatic effects are among the various pharmacological and biological effects of curcumin that have been reported by both in vitro and in vivo studies. Curcumin extract increases -cell functioning, delays the onset of diabetes, inhibits -cell death, and lowers insulin resistance in animal models. Recent preclinical studies and clinical trials have shown strong evidence of curcumin's vital roles in preventing type 2 diabetes via a number of pathways. Thus, the antidiabetic action of curcumin and its many mechanisms are comprehensively summarized in this study. The findings indicated that curcumin's anti-inflammatory, anti-oxidant, antihyperglycemic, antiapoptotic, and antihyperlipidemic properties, among others, account for its success in treating type 2 diabetes. These findings suggest that curcumin could be a potential option for T2DM prevention and management.
期刊介绍：
Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.
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