Beneficios de la prehabilitación en pacientes con cáncer colorrectal: estudio de casos y controles anidado

Q3 Medicine

Rehabilitacion Pub Date : 2025-06-04 DOI:10.1016/j.rh.2025.100918

E.J. Frutos-Reoyo , P. Luque-Linero , L. López-Maté , S. Rodríguez-Valbuena , Á. Serrano-Combarro , E.D. Candau-Pérez

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引用次数: 0

Abstract

Introduction and objective

Colorectal cancer (CRC) is one of the most prevalent and lethal malignancies worldwide. Surgical treatment is considered the gold standard. Prehabilitation emerges as a strategy integrating physical, nutritional, and psychological preparation before surgery. This study aimed to evaluate the effectiveness of prehabilitation in reducing hospital stay and mortality in CRC patients.

Material and method

A prospective observational nested case-control study within a cohort with a 24-month follow-up was conducted. Patients who underwent prehabilitation were defined as «cases» while those who did not were classified as «controls». Descriptive and analytical analyses were performed, with a significance level of p < 0.05. A Kaplan-Meier curve was used to assess survival concerning hospital stay and mortality.

Results

Of the 279 patients, 276 were analyzed (127 cases and 149 controls). The bivariate analysis showed comparable baseline characteristics between groups. The prehabilitation group demonstrated a significant reduction in postoperative hospital stay (4 days vs. 5 days; p = 0.02). No significant differences were observed in mortality (11.8% vs. 18.8%; p = 0.11).

Conclusions

The implementation of multimodal prehabilitation programs in CRC patients is associated with reduced hospital stay. Although no significant difference in mortality was observed, the trend suggests a positive impact. These findings support the adoption of prehabilitation as a standard in oncological practice.

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结直肠癌患者康复前的益处：病例研究和嵌套对照

简介与目的结直肠癌（colorectal cancer， CRC）是世界范围内最常见、最致命的恶性肿瘤之一。手术治疗被认为是金标准。术前康复是一种综合手术前身体、营养和心理准备的策略。本研究旨在评估康复治疗在减少结直肠癌患者住院时间和死亡率方面的有效性。材料与方法在随访24个月的队列中进行前瞻性观察巢式病例对照研究。接受康复治疗的患者被定义为“病例”，而未接受康复治疗的患者被归类为“对照组”。进行了描述性和分析性分析，显著性水平为p <；0.05. Kaplan-Meier曲线用于评估与住院时间和死亡率相关的生存率。结果279例患者中，分析276例（127例，对照组149例）。双变量分析显示各组之间的基线特征具有可比性。康复组术后住院时间显著缩短(4天vs. 5天；p = 0.02)。死亡率无显著差异(11.8% vs. 18.8%；p = 0.11)。结论在结直肠癌患者中实施多模式康复方案可减少住院时间。虽然没有观察到死亡率的显著差异，但这一趋势表明了积极的影响。这些发现支持将康复作为肿瘤学实践的标准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rehabilitacion Medicine-Rehabilitation

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： La revista que es desde hace más de 40 años la publicación oficial de la Sociedad Española de Rehabilitación y referente de la mayoría de las Sociedades de la Especialidad de los países americanos de habla hispana. Se publican 5 números pluritemáticos al año y uno monográfico sobre un tema del mayor interés y actualidad designado por el consejo de redacción.