Associations Between FTO Polymorphisms and Neuroblastoma Risk in Chinese Children.

IF 1.8 4区医学 Q3 PHARMACOLOGY & PHARMACY

Pharmacogenomics & Personalized Medicine Pub Date : 2025-05-27 eCollection Date: 2025-01-01 DOI:10.2147/PGPM.S488314

Peiqi Liu, Yue Li, Yong Li, Li Li, Jiwen Cheng, Suhong Li, Jiao Zhang, Haixia Zhou, Yunlong Huo, Zhonghua Yang, Jing He, Ran Zhang

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引用次数: 0

Abstract

Background: Neuroblastoma (NB) is a malignancy of neural crest cells that primarily affects children. Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene, a well-conserved gene, have been implicated in tumorigenesis. However, there is currently insufficient evidence to establish the relationship between FTO gene SNPs and susceptibility to NB.

Methods: A TaqMan assay was conducted to examine the potential associations between FTO gene SNPs and the risk of NB in a cohort of 898 patients and 1734 controls from eight medical centers in China. Additionally, stratification analysis was performed to evaluate the relationship between the selected FTO SNPs and the susceptibility to NB among various subgroups.

Results: No significant association was found between the selected FTO polymorphisms and the risk of NB in either the single locus analysis or the combined analysis.

Conclusion: However, our study reveals that individuals with retroperitoneal NB and those with stage III+IV NB are more prone to exhibit FTO SNPs compared to other patients. Moreover, participants with the FTO rs8047395 GG genotype displayed a higher likelihood of developing stage III+IV NB in comparison to other participants.

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中国儿童FTO多态性与神经母细胞瘤风险的关系

背景：神经母细胞瘤（NB）是一种主要影响儿童的神经嵴细胞恶性肿瘤。脂肪质量和肥胖相关基因（FTO）的单核苷酸多态性（snp）是一个保守的基因，与肿瘤的发生有关。然而，目前还没有足够的证据来建立FTO基因snp与NB易感性之间的关系。方法：采用TaqMan方法对来自中国8个医疗中心的898名患者和1734名对照者进行FTO基因snp与NB风险之间的潜在关联进行研究。此外，我们还进行了分层分析，以评估不同亚组中所选择的FTO snp与NB易感性之间的关系。结果：无论是单位点分析还是联合分析，所选择的FTO多态性与NB风险之间均未发现显著相关性。结论：然而，我们的研究显示，与其他患者相比，腹膜后NB患者和III+IV期NB患者更容易出现FTO snp。此外，与其他参与者相比，FTO rs8047395 GG基因型的参与者表现出更高的发展为III+IV期NB的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacogenomics & Personalized Medicine Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

3.30

自引率

5.30%

发文量

110

审稿时长

16 weeks

期刊介绍： Pharmacogenomics and Personalized Medicine is an international, peer-reviewed, open-access journal characterizing the influence of genotype on pharmacology leading to the development of personalized treatment programs and individualized drug selection for improved safety, efficacy and sustainability. In particular, emphasis will be given to: Genomic and proteomic profiling Genetics and drug metabolism Targeted drug identification and discovery Optimizing drug selection & dosage based on patient''s genetic profile Drug related morbidity & mortality intervention Advanced disease screening and targeted therapeutic intervention Genetic based vaccine development Patient satisfaction and preference Health economic evaluations Practical and organizational issues in the development and implementation of personalized medicine programs.