Effect of Laparoscopic Limited Anatomic Hepatectomy on Liver Function and Prognosis of Patients with Mid-Stage Gallbladder Cancer.

Abstract

Objective: Explore the effect of laparoscopic limited anatomic hepatectomy (LLAH) on liver function and prognosis of patients with midstage gallbladder cancer.

Methods: The 82 cases of midstage gallbladder cancer patients admitted to First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University from August 2018 to August 2022 were divided into groups according to surgical methods. Among them, 40 cases underwent traditional laparoscopic anatomic hepatectomy were classified as the traditional group, and 42 cases underwent LLAH were classified as the LLAH group. The perioperative indexes, liver function before and after operation, the complications and prognosis were compared between 2 groups.

Results: Compared with the traditional group, the LLAH group had longer operation time, less intraoperative blood loss and less postoperative hospital stay (P > .05). After surgery for 3 months, the levels of albumin (ALB) in 2 groups were higher than before surgery, while the levels of total bilirubin (TBIL), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were lower than before surgery, and the ALB level in LLAH group was higher than traditional group, the levels of TBIL, AST, and ALT were lower than those in traditional group (P > .05). The incidence of postoperative complications in LLAH group was lower than that in traditional group (P > .05). However, there was no significant difference in the 2-year postoperative survival rate between 2 groups (P > .05).

Conclusion: The treatment effect of LLAH for patients with midstage gallbladder cancer is significant. It can reduce intraoperative bleeding, shorten postoperative hospital stay, improve liver function, and decrease complications.