The effects of oxygen-ozone therapy in knee osteoarthritis: A systematic review.

IF 1.4 4区医学 Q3 ORTHOPEDICS

Journal of Back and Musculoskeletal Rehabilitation Pub Date : 2025-06-02 DOI:10.1177/10538127251341834

Giacomo Farì, Annatonia Fai, Danilo Donati, Roberto Tedeschi, Giustino Varrassi, Vincenzo Ricci, Cristiano Sconza, Alessio Baricich, Andrea Bernetti

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引用次数: 0

Abstract

IntroductionOxygen-ozone therapy (OOT) is an innovative treatment showing potential for various conditions, including knee osteoarthritis (KOA), a joint disorder causing cartilage degeneration, inflammation, and pain. This review evaluates OOT's effectiveness in treating KOA, focusing on pain relief, joint function, and quality of life.Materials and MethodsThe review synthesizes findings from five randomized controlled trials (RCTs) comparing OOT with standard treatments such as corticosteroids, hyaluronic acid, and placebo, assessing its effects on pain relief, joint function, and quality of life.ResultsOOT significantly reduces pain and improves joint mobility in KOA patients, with some studies reporting longer-lasting effects than corticosteroids. OOT also shows anti-inflammatory benefits by reducing pro-inflammatory cytokines, suggesting a potential to modify disease mechanisms. It is minimally invasive and has fewer side effects compared to traditional treatments.ConclusionsOOT presents a promising alternative to conventional treatments, offering pain relief, functional improvement, and safety benefits. Despite some limitations, such as treatment variability and lack of long-term follow-up, OOT is a valuable therapeutic option for KOA.

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氧臭氧治疗膝关节骨性关节炎的疗效：一项系统综述。

氧臭氧疗法（OOT）是一种创新的治疗方法，显示出治疗多种疾病的潜力，包括膝骨关节炎（KOA），一种引起软骨变性、炎症和疼痛的关节疾病。本综述评估OOT治疗KOA的有效性，重点关注疼痛缓解、关节功能和生活质量。材料和方法本综述综合了五项随机对照试验（rct）的结果，将OOT与皮质类固醇、透明质酸和安慰剂等标准治疗方法进行比较，评估其对疼痛缓解、关节功能和生活质量的影响。结果oot可显著减轻KOA患者的疼痛并改善关节活动能力，一些研究报告其效果比皮质类固醇更持久。OOT还通过减少促炎细胞因子显示出抗炎作用，这表明它有可能改变疾病机制。与传统的治疗方法相比，它是微创的，副作用也更少。结论烟灰是一种很有前景的替代传统治疗方法，具有疼痛缓解、功能改善和安全性方面的优势。尽管存在一些局限性，如治疗的可变性和缺乏长期随访，OOT仍然是KOA的一种有价值的治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Back and Musculoskeletal Rehabilitation 医学-康复医学

CiteScore

2.70

自引率

0.00%

发文量

194

审稿时长

6 months

期刊介绍： The Journal of Back and Musculoskeletal Rehabilitation is a journal whose main focus is to present relevant information about the interdisciplinary approach to musculoskeletal rehabilitation for clinicians who treat patients with back and musculoskeletal pain complaints. It will provide readers with both 1) a general fund of knowledge on the assessment and management of specific problems and 2) new information considered to be state-of-the-art in the field. The intended audience is multidisciplinary as well as multi-specialty. In each issue clinicians can find information which they can use in their patient setting the very next day.