{"title":"Physical Activity and Sedentary Time Correlate with Body Composition in Patients with Asthma; a Multicenter Observational Study.","authors":"Mayuka Yamane, Hiroshi Iwamoto, Kazuma Kawamoto, Toshihito Otani, Naoko Higaki, Keita Murakawa, Ayumi Fukatsu-Chikumoto, Tsunahiko Hirano, Yoshihiro Amano, Takeshi Isobe, Kazuto Matsunaga, Noboru Hattori, Akihito Yokoyama","doi":"10.2147/JAA.S514541","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Increasing physical activity is recommended as a non-pharmacological approach for improving the symptoms, quality of life, and overall health in patients with asthma. However, the systemic effect of physical activity, especially sedentary behavior, in patients with asthma remains unclear.</p><p><strong>Objective: </strong>The aim of this study was to investigate the association of objectively measured physical activity, including sedentary time, with body composition data and clinical characteristics in patients with asthma.</p><p><strong>Methods: </strong>The study included 85 patients with asthma and 38 healthy controls. Physical activity indices were assessed for 2 weeks using accelerometers. We investigated the relationship between physical activity levels and clinical characteristics, along with its association with body composition data assessed using dual-energy X-ray absorptiometry and computed tomography in patients with asthma.</p><p><strong>Results: </strong>In patients with asthma, high blood eosinophil counts and poor asthma control, as assessed by the Asthma Control Questionnaire score, were associated with prolonged sedentary time and reduced step count. Moreover, reduced step count was independently associated with an elevated fat mass index, whereas a prolonged sedentary time and high oral corticosteroid doses were independently associated with a low lean mass index in patients with asthma. Prolonged sedentary time demonstrated a negative correlation with erector spinae muscle area after adjusting for background factors.</p><p><strong>Conclusion: </strong>Sedentary behavior and physical inactivity are associated with body composition in patients with asthma, suggesting the need for interventions targeting these behaviors to improve health outcomes.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"835-846"},"PeriodicalIF":3.0000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126974/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asthma and Allergy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JAA.S514541","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ALLERGY","Score":null,"Total":0}
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Abstract
Background: Increasing physical activity is recommended as a non-pharmacological approach for improving the symptoms, quality of life, and overall health in patients with asthma. However, the systemic effect of physical activity, especially sedentary behavior, in patients with asthma remains unclear.
Objective: The aim of this study was to investigate the association of objectively measured physical activity, including sedentary time, with body composition data and clinical characteristics in patients with asthma.
Methods: The study included 85 patients with asthma and 38 healthy controls. Physical activity indices were assessed for 2 weeks using accelerometers. We investigated the relationship between physical activity levels and clinical characteristics, along with its association with body composition data assessed using dual-energy X-ray absorptiometry and computed tomography in patients with asthma.
Results: In patients with asthma, high blood eosinophil counts and poor asthma control, as assessed by the Asthma Control Questionnaire score, were associated with prolonged sedentary time and reduced step count. Moreover, reduced step count was independently associated with an elevated fat mass index, whereas a prolonged sedentary time and high oral corticosteroid doses were independently associated with a low lean mass index in patients with asthma. Prolonged sedentary time demonstrated a negative correlation with erector spinae muscle area after adjusting for background factors.
Conclusion: Sedentary behavior and physical inactivity are associated with body composition in patients with asthma, suggesting the need for interventions targeting these behaviors to improve health outcomes.
期刊介绍：
An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies.
Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.
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