Association Between Blood Lead Levels and Diabetic Kidney Disease: A Cross-sectional Analysis of NHANES Data (1999-2018).

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current molecular medicine Pub Date : 2025-05-29 DOI:10.2174/0115665240293441250312133508

Yaxian Ning, Jianqin Wang, Xiaochun Zhou, Gouqin Wang, Lili Zhang

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引用次数: 0

Abstract

Background: The relationship between heavy metals, particularly lead (Pb), and diabetic kidney disease (DKD) remains unclear, especially regarding exposure thresholds. This study investigates the association between blood Pb levels and DKD risk using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018.

Methods: A total of 1,343 participants were included, with 508 diagnosed with DKD. Baseline characteristics were compared between DKD and non-DKD groups. Multivariate generalized linear models (GLMs) and weighted logistic regression were used to assess correlations between blood Pb levels and DKD risk. A nomogram was developed to evaluate the predictive power of significant clinical characteristics.

Results: Key clinical characteristics, including age, marital status, and serum Pb levels, differed significantly between DKD and non-DKD groups. Serum Pb was identified as a significant risk factor (ORs: 1.18-1.39, p < 0.01). The nomogram demonstrated good predictive accuracy (AUC = 0.717).

Conclusion: Elevated blood Pb levels are significantly associated with DKD, with a non-linear relationship and a defined threshold. These findings highlight the potential role of Pb exposure in DKD pathogenesis and suggest the utility of blood Pb monitoring in diabetic patients.

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血铅水平与糖尿病肾病之间的关系：NHANES数据的横断面分析（1999-2018）。

背景：重金属，特别是铅（Pb）与糖尿病肾病（DKD）之间的关系尚不清楚，特别是在暴露阈值方面。本研究利用1999年至2018年国家健康与营养检查调查（NHANES）的数据调查了血铅水平与DKD风险之间的关系。方法：共纳入1,343名参与者，其中508名被诊断为DKD。比较DKD组和非DKD组的基线特征。采用多元广义线性模型（GLMs）和加权逻辑回归评估血铅水平与DKD风险之间的相关性。开发了一种nomogram来评估重要临床特征的预测能力。结果：关键临床特征，包括年龄、婚姻状况和血清铅水平，在DKD组和非DKD组之间存在显著差异。血清铅是显著危险因素（or: 1.18 ~ 1.39, p < 0.01）。nomogram具有较好的预测准确度（AUC = 0.717）。结论：血铅水平升高与DKD显著相关，呈非线性关系，且有一定阈值。这些发现强调了铅暴露在DKD发病机制中的潜在作用，并提示了糖尿病患者血铅监测的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current molecular medicine 医学-医学：研究与实验

CiteScore

5.00

自引率

4.00%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.