Revolutionary Regeneration Therapy Utilizing Dental Stem Cells and State-of-the-Art Nanotechnology Devices to Heal Injured Teeth and Tissues.

Q3 Biochemistry, Genetics and Molecular Biology
Mohammad Balfaki, Erfan Salimi
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引用次数: 0

Abstract

Regenerative medicine is a field of pharmacy and medicine that focuses on stem cells and other methods such as nanoscience and biotechnology to stimulate the body's natural regenerative processes and repairing damaged tissues and organs to improve function and reduce pain. In this review article, focus is on Dental Stem Cells (DSC) and other cells regeneration in human body. The appropriateness of tissue-engineered therapies relying on the multipotent regenerative abilities of DSC is accompanied by significant challenges, as growth factors and epigenetic components are crucial for preserving their multipotency while being susceptible to a range of natural and environmental factors. Current evidence highlights the positive outcomes associated with select regenerative therapies; nevertheless, to provide further support, additional data must be gathered through standardized therapies and further studies. Organoids (3D cell culture) and nano scaffolds are also being explored as potential tools for regenerative therapies. Understanding the mechanisms that determine the behavior of these cells and how they interact will enable future generation therapies. Demonstrating promise, cell therapy is an alternative approach within regenerative medicine. Developmental factors like extracellular vesicle production are thought to mediate the regenerative response through paracrine effects in cell therapy, which is widely recognized.

利用牙科干细胞和最先进的纳米技术设备的革命性再生疗法来治愈受伤的牙齿和组织。
再生医学是一个药学和医学领域,专注于干细胞和其他方法,如纳米科学和生物技术,以刺激身体的自然再生过程和修复受损的组织和器官,以改善功能和减轻疼痛。本文就牙干细胞及其在人体内的再生研究进展作一综述。依赖于DSC多能再生能力的组织工程疗法的适当性伴随着重大挑战,因为生长因子和表观遗传成分对于保持其多能性至关重要,同时易受一系列自然和环境因素的影响。目前的证据强调了与选择再生疗法相关的积极结果;然而,为了提供进一步的支持,必须通过标准化治疗和进一步研究收集更多的数据。类器官(3D细胞培养)和纳米支架也正在被探索作为再生治疗的潜在工具。了解决定这些细胞行为的机制以及它们如何相互作用将使未来的治疗成为可能。细胞疗法是再生医学中的一种替代方法,显示了它的前景。细胞外囊泡生成等发育因素被认为通过细胞治疗中的旁分泌作用介导再生反应,这一点已得到广泛认可。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Avicenna journal of medical biotechnology
Avicenna journal of medical biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
2.90
自引率
0.00%
发文量
43
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