Fluoride: a double-edged sword in public health and environmental toxicology.

IF 3 4区环境科学与生态学 Q3 ENVIRONMENTAL SCIENCES

Environmental Monitoring and Assessment Pub Date : 2025-06-02 DOI:10.1007/s10661-025-14175-3

Maísa Rizzotto Sotili, Tatiana Staudt, Diênifer Tramontina, Nathalia de Souza Rodrigues, Gabriele Luiza Alba, Vitória Citolin Crestani, Hamid Omidian, Charise Dallazem Bertol

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引用次数: 0

Abstract

Fluoride exposure has raised global concerns due to its potential neurodevelopmental, systemic, and ecological impacts. This review consolidates advancements in fluoride toxicity, highlighting molecular mechanisms like mitochondrial dysfunction, autophagy disruption, and epigenetic alterations. Prenatal exposure is linked to cognitive deficits, while systemic effects include renal, hepatic, and thyroid dysfunction. Novel therapeutic strategies, such as natural compounds and microbiota modulation, offer promise, but translational barriers persist. Real-world co-exposures amplify toxicity, underscoring the need for interdisciplinary research. Environmental contamination challenges demand innovative remediation and global policy reform. This review identifies key knowledge gaps, advocating for longitudinal studies, multi-omics integration, and sustainable interventions to mitigate fluoride's health burden and ecological risks. These findings lay a foundation for targeted public health strategies.

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氟化物：公共卫生和环境毒理学的双刃剑。

氟化物暴露因其潜在的神经发育、系统和生态影响而引起全球关注。本文综述了氟化物毒性的研究进展，强调了线粒体功能障碍、自噬破坏和表观遗传改变等分子机制。产前暴露与认知缺陷有关，而全身影响包括肾脏、肝脏和甲状腺功能障碍。新的治疗策略，如天然化合物和微生物群调节，提供了希望，但翻译障碍仍然存在。现实世界的共同暴露放大了毒性，强调了跨学科研究的必要性。环境污染挑战需要创新的补救措施和全球政策改革。本综述确定了关键的知识差距，倡导纵向研究、多组学整合和可持续干预措施，以减轻氟化物的健康负担和生态风险。这些发现为有针对性的公共卫生战略奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Monitoring and Assessment 环境科学-环境科学

CiteScore

4.70

自引率

6.70%

发文量

1000

审稿时长

7.3 months

期刊介绍： Environmental Monitoring and Assessment emphasizes technical developments and data arising from environmental monitoring and assessment, the use of scientific principles in the design of monitoring systems at the local, regional and global scales, and the use of monitoring data in assessing the consequences of natural resource management actions and pollution risks to man and the environment.