Azide as a photolabile ligand in gold(I) therapeutics

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry Pub Date : 2025-05-26 DOI:10.1016/j.jorganchem.2025.123724

Jan Romano-deGea , Zhenhua Chen , Kedar A. Abhyankar , Rosario Scopelliti , Farzaneh Fadaei-Tirani , Kevin Cariou , Gilles Gasser , Paul J. Dyson

引用次数: 0

Abstract

Gold-based compounds are gaining attention as potential alternatives to platinum-based chemotherapeutics due to their high antiproliferative activity and unique mechanisms of action. However, challenges remain in enhancing their selectivity and reducing side effects. In this study, we synthesized and characterized a series of gold(I) azido complexes featuring phosphine and N-heterocyclic carbene ligands. Their cytotoxicity was assessed against human lung carcinoma (A549) and non-cancerous fibroblast (MRC-5) cells, revealing micromolar-range antiproliferative effects with varying selectivity. Additionally, their use as photoactivated chemotherapy (PACT) agents was explored, with some complexes displaying modulation of their cytotoxicity upon light exposure. These findings suggest that gold azido complexes could serve as promising drug candidates for chemotherapy treatments.

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叠氮化物在金治疗中的光稳定性（一）

金基化合物因其高抗增殖活性和独特的作用机制而成为铂基化疗药物的潜在替代品。然而，在提高它们的选择性和减少副作用方面仍然存在挑战。在本研究中，我们合成并表征了一系列以膦和n杂环碳烷为配体的金(I)叠氮配合物。对其对人肺癌（A549）和非癌成纤维细胞（MRC-5）的细胞毒性进行了评估，揭示了微磨牙范围内不同选择性的抗增殖作用。此外，它们作为光活化化疗（PACT）药物的使用也被探索，一些复合物在光照射下显示出它们的细胞毒性调节。这些发现表明，金叠氮配合物可以作为化疗的有希望的候选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organometallic Chemistry 化学-无机化学与核化学

CiteScore

4.40

自引率

8.70%

发文量

221

审稿时长

36 days

期刊介绍： The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.