Expanding the Diversity of the Terpene Skeleton and Structure through Identification of Noncanonical Class IE and IF Terpene Synthase-Formed Products

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-06-02 DOI:10.1021/acs.orglett.5c01879

Tohru Abe, Tohru Taniguchi, Daijiro Ueda, Takashi Abe, Tsutomu Sato

引用次数: 0

Abstract

Noncanonical class IE and IF terpene synthases have recently been discovered from bacterial genomes through the nonsequence-similarity-based method: protein-structural-model-based genome mining. This study identified the class IE product as a new diterpene comprising the first hydrocarbon skeleton among all terpenoids. The skeleton with a 6/6/6-fused tricyclic structure and six methyl groups could be synthesized through an unprecedented terpene-forming reaction. The class IF product was identified as a new brasilane-type sesquiterpene.

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通过鉴定非规范类IE和IF萜烯合酶形成的产物扩大萜烯骨架和结构的多样性

最近，通过基于非序列相似性的方法：基于蛋白质结构模型的基因组挖掘，从细菌基因组中发现了非规范类IE和IF萜烯合成酶。本研究鉴定了IE类产物为一种新的二萜，在所有萜类化合物中含有第一碳氢骨架。通过前所未有的萜烯生成反应，可以合成具有6/6/6-融合三环结构和6个甲基的骨架。经鉴定，该IF类产物为一种新型巴西烷型倍半萜。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.